TY - JOUR
T1 - Recognition of tumor glycans by antigen-presenting cells
AU - Aarnoudse, Corlien A
AU - Garcia Vallejo, Juan J
AU - Saeland, Eiríkur
AU - van Kooyk, Yvette
PY - 2006/2
Y1 - 2006/2
N2 - C-type lectin receptors on antigen-presenting cells are potent antigen-uptake receptors with specificity for glycan structures. Glycosylation changes during malignant transformation create tumor-specific carbohydrate structures that interact with C-type lectins on dendritic cells. Recent findings revealed that tumor glycoproteins, such as carcinoembryonic antigen and MUC-1, indeed interact with the C-type lectins DC-SIGN and macrophage galactose-type lectin on antigen-presenting cells. The consequences for anti-cancer immunity or tolerance induction can be extrapolated from the function of C-type lectins in pathogen recognition and antigen presentation. In addition, in vivo studies in mice recently demonstrated the potency of targeting antigens to C-type lectins on antigen-presenting cells for anti-tumor vaccination strategies.
AB - C-type lectin receptors on antigen-presenting cells are potent antigen-uptake receptors with specificity for glycan structures. Glycosylation changes during malignant transformation create tumor-specific carbohydrate structures that interact with C-type lectins on dendritic cells. Recent findings revealed that tumor glycoproteins, such as carcinoembryonic antigen and MUC-1, indeed interact with the C-type lectins DC-SIGN and macrophage galactose-type lectin on antigen-presenting cells. The consequences for anti-cancer immunity or tolerance induction can be extrapolated from the function of C-type lectins in pathogen recognition and antigen presentation. In addition, in vivo studies in mice recently demonstrated the potency of targeting antigens to C-type lectins on antigen-presenting cells for anti-tumor vaccination strategies.
KW - Animals
KW - Antigen-Presenting Cells/chemistry
KW - Antigens, Neoplasm/immunology
KW - Carcinoembryonic Antigen/immunology
KW - Glycosylation
KW - Humans
KW - Immunotherapy
KW - Lectins, C-Type/chemistry
KW - Mice
KW - Neoplasms/immunology
KW - Polysaccharides/immunology
KW - Receptors, Cell Surface/immunology
U2 - 10.1016/j.coi.2005.11.001
DO - 10.1016/j.coi.2005.11.001
M3 - Review article
C2 - 16303292
VL - 18
SP - 105
EP - 111
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 1
ER -