Recruitment of antigen-specific CD8+ T cells in response to infection is markedly efficient

Jeroen W J van Heijst, Carmen Gerlach, Erwin Swart, Daoud Sie, Cláudio Nunes-Alves, Ron M Kerkhoven, Ramon Arens, Margarida Correia-Neves, Koen Schepers, Ton N M Schumacher

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The magnitude of antigen-specific CD8+ T cell responses is not fixed but correlates with the severity of infection. Although by definition T cell response size is the product of both the capacity to recruit naïve T cells (clonal selection) and their subsequent proliferation (clonal expansion), it remains undefined how these two factors regulate antigen-specific T cell responses. We determined the relative contribution of recruitment and expansion by labeling naïve T cells with unique genetic tags and transferring them into mice. Under disparate infection conditions with different pathogens and doses, recruitment of antigen-specific T cells was near constant and close to complete. Thus, naïve T cell recruitment is highly efficient, and the magnitude of antigen-specific CD8+ T cell responses is primarily controlled by clonal expansion.

Original languageEnglish
Pages (from-to)1265-9
Number of pages5
JournalScience
Volume325
Issue number5945
DOIs
Publication statusPublished - 4 Sep 2009

Cite this