TY - JOUR
T1 - Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis
AU - Berkers, Gitte
AU - van Mourik, Peter
AU - Vonk, Annelotte M.
AU - Kruisselbrink, Evelien
AU - Dekkers, Johanna F.
AU - de Winter-de Groot, Karin M.
AU - Arets, Hubertus G. M.
AU - Marck-van der Wilt, Rozemarijn E. P.
AU - Dijkema, Jasper S.
AU - Vanderschuren, Maaike M.
AU - Houwen, Roderick H. J.
AU - Heijerman, Harry G. M.
AU - van de Graaf, Eduard A.
AU - Elias, Sjoerd G.
AU - Majoor, Christof J.
AU - Koppelman, Gerard H.
AU - Roukema, Jolt
AU - Bakker, Marleen
AU - Janssens, Hettie M.
AU - van der Meer, Renske
AU - Vries, Robert G. J.
AU - Clevers, Hans C.
AU - de Jonge, Hugo R.
AU - Beekman, Jeffrey M.
AU - van der Ent, Cornelis K.
PY - 2019/2/12
Y1 - 2019/2/12
N2 - Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.
AB - Berkers et al. demonstrate that stem cell cultures (organoids) can be a tool for personalized medicine. They show a high correlation between in vitro and in vivo effects of drugs and demonstrate good-to-excellent predictive values of the organoid test for preclinical identification of responders to CFTR modulators.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061162213&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30759382
U2 - 10.1016/j.celrep.2019.01.068
DO - 10.1016/j.celrep.2019.01.068
M3 - Article
C2 - 30759382
SN - 2211-1247
VL - 26
SP - 1701-1708.e3
JO - Cell Reports
JF - Cell Reports
IS - 7
ER -