Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect

Ingrid P. Vogelaar, Marjolijn J.L. Ligtenberg, Rachel S. van der Post, Richarda M. de Voer, C. Marleen Kets, Trees J.G. Jansen, Liesbeth Jacobs, Gerty Schreibelt, I. Jolanda M. de Vries, Mihai G. Netea, Nicoline Hoogerbrugge, International Gastric Cancer Genetics Group

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalFamilial Cancer
Volume15
Issue number2
DOIs
Publication statusPublished - 1 Apr 2016

Cite this

Vogelaar, I. P., Ligtenberg, M. J. L., van der Post, R. S., de Voer, R. M., Kets, C. M., Jansen, T. J. G., ... International Gastric Cancer Genetics Group (2016). Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect. Familial Cancer, 15(2), 289-296. https://doi.org/10.1007/s10689-015-9859-z
Vogelaar, Ingrid P. ; Ligtenberg, Marjolijn J.L. ; van der Post, Rachel S. ; de Voer, Richarda M. ; Kets, C. Marleen ; Jansen, Trees J.G. ; Jacobs, Liesbeth ; Schreibelt, Gerty ; de Vries, I. Jolanda M. ; Netea, Mihai G. ; Hoogerbrugge, Nicoline ; International Gastric Cancer Genetics Group. / Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect. In: Familial Cancer. 2016 ; Vol. 15, No. 2. pp. 289-296.
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title = "Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect",
abstract = "Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.",
keywords = "Candidaalbicans, Gastric cancer, Interleukin-17, MYD88, Th17 response",
author = "Vogelaar, {Ingrid P.} and Ligtenberg, {Marjolijn J.L.} and {van der Post}, {Rachel S.} and {de Voer}, {Richarda M.} and Kets, {C. Marleen} and Jansen, {Trees J.G.} and Liesbeth Jacobs and Gerty Schreibelt and {de Vries}, {I. Jolanda M.} and Netea, {Mihai G.} and Nicoline Hoogerbrugge and Jan Lubinski and Anna Jakubowska and Urszula Teodorczyk and Schackert, {Hans K.} and Aalfs, {Cora M.} and {G{\'o}mez Garc{\'i}a}, {Encarna B.} and Ranzani, {Guglielmina N.} and Valeria Molinaro and {van Hest}, {Liselotte P.} and Hes, {Frederik J.} and Elke Holinski-Feder and Maurizio Genuardi and Ausems, {Margreet G.E.M.} and Sijmons, {Rolf H.} and Anja Wagner and {van der Kolk}, {Lizet E.} and Hugo Pinheiro and Carla Oliveira and Inga Bj{\o}rnevoll and {H{\o}berg Vetti}, Hildegunn and J. Han and {van Krieken}, {J. M.} and {International Gastric Cancer Genetics Group}",
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Vogelaar, IP, Ligtenberg, MJL, van der Post, RS, de Voer, RM, Kets, CM, Jansen, TJG, Jacobs, L, Schreibelt, G, de Vries, IJM, Netea, MG, Hoogerbrugge, N & International Gastric Cancer Genetics Group 2016, 'Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect' Familial Cancer, vol. 15, no. 2, pp. 289-296. https://doi.org/10.1007/s10689-015-9859-z

Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect. / Vogelaar, Ingrid P.; Ligtenberg, Marjolijn J.L.; van der Post, Rachel S.; de Voer, Richarda M.; Kets, C. Marleen; Jansen, Trees J.G.; Jacobs, Liesbeth; Schreibelt, Gerty; de Vries, I. Jolanda M.; Netea, Mihai G.; Hoogerbrugge, Nicoline; International Gastric Cancer Genetics Group.

In: Familial Cancer, Vol. 15, No. 2, 01.04.2016, p. 289-296.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Ligtenberg, Marjolijn J.L.

AU - van der Post, Rachel S.

AU - de Voer, Richarda M.

AU - Kets, C. Marleen

AU - Jansen, Trees J.G.

AU - Jacobs, Liesbeth

AU - Schreibelt, Gerty

AU - de Vries, I. Jolanda M.

AU - Netea, Mihai G.

AU - Hoogerbrugge, Nicoline

AU - Lubinski, Jan

AU - Jakubowska, Anna

AU - Teodorczyk, Urszula

AU - Schackert, Hans K.

AU - Aalfs, Cora M.

AU - Gómez García, Encarna B.

AU - Ranzani, Guglielmina N.

AU - Molinaro, Valeria

AU - van Hest, Liselotte P.

AU - Hes, Frederik J.

AU - Holinski-Feder, Elke

AU - Genuardi, Maurizio

AU - Ausems, Margreet G.E.M.

AU - Sijmons, Rolf H.

AU - Wagner, Anja

AU - van der Kolk, Lizet E.

AU - Pinheiro, Hugo

AU - Oliveira, Carla

AU - Bjørnevoll, Inga

AU - Høberg Vetti, Hildegunn

AU - Han, J.

AU - van Krieken, J. M.

AU - International Gastric Cancer Genetics Group

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AB - Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.

KW - Candidaalbicans

KW - Gastric cancer

KW - Interleukin-17

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Vogelaar IP, Ligtenberg MJL, van der Post RS, de Voer RM, Kets CM, Jansen TJG et al. Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect. Familial Cancer. 2016 Apr 1;15(2):289-296. https://doi.org/10.1007/s10689-015-9859-z