Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

Erik A. H. Loeffen, Leontien C. M. Kremer, Marianne D. van de Wetering, Renée L. Mulder, Anna Font-Gonzalez, Lee L. Dupuis, Fiona Campbell, Wim J. E. Tissing, on behalf of the Pain in Children with Cancer Guideline Development Panel, Doralina L. Anghelescu, Kathryn Birnie, Judith de Bont, Amy-Lee Bredlau, Patsy Cullen, Sarah Daniels, Bruce Dick, Monique van Dijk, R. Scott Dingeman, Elena Evan, Julie GeggFaith Gibson, Martine van Grotel, Lindsay Jibb, Roy Kao, Rutger Knops, Ketan Kulkarni, Piet Leroy, Christina Liossi, Gustaf Ljungman, Jennifer McLean, Maarten Mensink, Erna Michiels, Mary Ann Muckaden, Brittney Newman, Karyn Positano, Mienke Rijsdijk, Emily Rowe, Gurjit Sangha, Jennifer Stinson, Anna Taddio, Hannah Taylor, Perri Tutelman, Alison Twycross, Marc Wijnen, Lonnie Zeltzer

Research output: Contribution to journalArticleAcademicpeer-review


Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient representatives, we aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological, and physical management of tumor-, treatment-, and procedure-related pain in children with cancer. In this paper, we present our thorough methodology for this development, including the challenges we faced and how we approached these. This lays the foundation for our clinical practice guideline, for which there is a high clinical demand.
Original languageEnglish
Article numbere27698
JournalPediatric Blood and Cancer
Issue number6
Publication statusPublished - 1 Jun 2019

Cite this