The development of a labeling method for secondary amines with [2- 11C]acetone is described since the R2N-isopropyl moiety is present in many biologically active compounds. The influence of a variety of parameters (e.g. reagents, solvents, temperature, and time) on the reaction outcome is discussed. Under the optimal reaction conditions, [ 11C]1-isopropyl-4-phenylpiperazine ([11C]iPPP) was synthesized from [2-11C]acetone and 1-phenylpiperazine in a decay-corrected radiochemical yield of 72%. The overall synthesis time, from EOB to HPLC analysis of [11C]iPPP, was 20 min. Specific activity was 142-208 GBq/μmol at the end of synthesis.
|Number of pages||11|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publication status||Published - 1 Oct 2003|