Regional grey matter volume and concentration in at-risk adolescents: Untangling associations with callous-unemotional traits and conduct disorder symptoms

Moran D Cohn, Essi Viding, Eamon McCrory, Louise Pape, Wim van den Brink, Theo A H Doreleijers, Dick J Veltman, Arne Popma

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7yr), characterized by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.

Original languageEnglish
Pages (from-to)180-7
Number of pages8
JournalPsychiatry Research
Volume254
DOIs
Publication statusPublished - 30 Aug 2016

Cite this

Cohn, Moran D ; Viding, Essi ; McCrory, Eamon ; Pape, Louise ; van den Brink, Wim ; Doreleijers, Theo A H ; Veltman, Dick J ; Popma, Arne. / Regional grey matter volume and concentration in at-risk adolescents : Untangling associations with callous-unemotional traits and conduct disorder symptoms. In: Psychiatry Research. 2016 ; Vol. 254. pp. 180-7.
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abstract = "Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7yr), characterized by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.",
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Regional grey matter volume and concentration in at-risk adolescents : Untangling associations with callous-unemotional traits and conduct disorder symptoms. / Cohn, Moran D; Viding, Essi; McCrory, Eamon; Pape, Louise; van den Brink, Wim; Doreleijers, Theo A H; Veltman, Dick J; Popma, Arne.

In: Psychiatry Research, Vol. 254, 30.08.2016, p. 180-7.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Cohn, Moran D

AU - Viding, Essi

AU - McCrory, Eamon

AU - Pape, Louise

AU - van den Brink, Wim

AU - Doreleijers, Theo A H

AU - Veltman, Dick J

AU - Popma, Arne

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/8/30

Y1 - 2016/8/30

N2 - Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7yr), characterized by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.

AB - Structural Magnetic Resonance Imaging studies have reported volume reductions in several brain regions implicated in social cognition and emotion recognition in juvenile antisocial populations. However, it is unclear whether these structural abnormalities are specifically related to antisocial features, or to co-occurring callous-unemotional (CU) traits. The present study employed voxel-based morphometry to assess both grey matter volume (GMV) and grey matter concentration (GMC) in a large representative at-risk sample of adolescents (n=134; mean age 17.7yr), characterized by a broad range of CU trait and conduct disorder (CD) symptom scores. There was a significant interaction between CD symptom and CU trait scores in the prediction of GMV in the anterior insula, with a significant positive association between CU traits and GMV in youth low on CD symptoms only. In addition, we found a significant unique positive association between CD symptoms and GMC in the amygdala, and unique negative associations between CU traits and GMC in the amygdala and insula. These findings are in line with accumulating evidence of distinct associations of CD symptoms and CU traits with amygdala and insula GMC in juvenile antisocial populations.

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