Relation between coupling index and ejection fraction and the alternative starling curve

Peter L.M. Kerkhof*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Volume changes and pressure variations are fundamental determinants of ventricular functioning. Ventricular end-systolic elastance (Emax) depends on ejection pressure and end-systolic volume, whereas arterial elastance (Ea) refers to the ratio of ejection pressure and stroke volume. Coupling between left ventricle and arterial bed has often been quantitated by using the ratio of Emax and Ea. Reportedly, this ratio equals to one for optimal coupling conditions, but measurements in humans documented values considerably different from unity.We modelled the behavior of the left ventricle on the basis of the experimentally constructed Alternative Starling curve (ASC). Such relation describes the dynamic behavior of the volume regulation for the heart. This information was then applied to relate Emax/Ea to ejection fraction (EF). Our results indicate that Emax/Ea varies with the prevailing value of EF. Also, this outcome explains seemingly conflicting findings obtained in cardiac patients.

Original languageEnglish
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
EditorsAndrew Y.J. Szeto, Rangaraj M. Rangayyan
PublisherPubl by IEEE
Pages907-908
Number of pages2
Editionpt 2
ISBN (Print)0780313771
Publication statusPublished - 1 Dec 1993
Externally publishedYes
EventProceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3) - San Diego, CA, USA
Duration: 28 Oct 199331 Oct 1993

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 2
Volume15
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3)
CitySan Diego, CA, USA
Period28/10/199331/10/1993

Cite this

Kerkhof, P. L. M. (1993). Relation between coupling index and ejection fraction and the alternative starling curve. In A. Y. J. Szeto, & R. M. Rangayyan (Eds.), Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., pp. 907-908). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; Vol. 15, No. pt 2). Publ by IEEE.