Relation of Resting Heart Rate to Prognosis in Patients With Idiopathic Pulmonary Arterial Hypertension

I.R. Henkens, S.A. van Wolferen, C.T. Gan, A. Boonstra, C.A. Swenne, J.W.R. Twisk, O. Kamp, E.E. van der Wall, M.J. Schalij, A. Vonk noordegraaf, H.W. Vliegen

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Abstract

Heart rate (HR) at rest is an important marker of prognosis in heart failure, but has not been addressed in pulmonary arterial hypertension (PAH). To determine the prognostic value of HR at rest in patients with PAH, we retrospectively analyzed 140 consecutive patients with idiopathic PAR Electrocardiogram (ECG)-derived HR at rest was evaluated as a potential predictor of adverse prognosis (death or lung transplantation), in addition to World Health Organization functional class, 6-minute walk distance, and hemodynamics before and approximately 1 year and 2 years after initiation of PAH treatment. During follow-up, 49 patients (35%) died, and 5 patients (4%) underwent lung transplantation. Before treatment initiation and after 1 year and 2 years of treatment, respectively, a higher HR at rest was an independent predictor of adverse prognosis (hazard ratios per 10-beats/min increase 1.76, 95% confidence interval 1.42 to 2.18, 2.31, 95% confidence interval 1.58 to 3.38, 2.1, 95% confidence interval 1.39 to 3.19, respectively, p
Original languageUndefined/Unknown
Pages (from-to)1451-1456
JournalAmerican Journal of Cardiology
Volume103
Issue number10
DOIs
Publication statusPublished - 2009

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