Relationship between pernicious anaemia and gastric neuroendocrine cell disorders

A M Spoelstra-de Man, S S Wagenaar, A van der Sluys Veer, C B Brouwer

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65%) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise.

Original languageEnglish
Pages (from-to)56-62
Number of pages7
JournalNetherlands Journal of Medicine
Volume56
Issue number2
Publication statusPublished - Feb 2000

Cite this

Spoelstra-de Man, A M ; Wagenaar, S S ; van der Sluys Veer, A ; Brouwer, C B. / Relationship between pernicious anaemia and gastric neuroendocrine cell disorders. In: Netherlands Journal of Medicine. 2000 ; Vol. 56, No. 2. pp. 56-62.
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title = "Relationship between pernicious anaemia and gastric neuroendocrine cell disorders",
abstract = "The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65{\%}) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise.",
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author = "{Spoelstra-de Man}, {A M} and Wagenaar, {S S} and {van der Sluys Veer}, A and Brouwer, {C B}",
year = "2000",
month = "2",
language = "English",
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Spoelstra-de Man, AM, Wagenaar, SS, van der Sluys Veer, A & Brouwer, CB 2000, 'Relationship between pernicious anaemia and gastric neuroendocrine cell disorders' Netherlands Journal of Medicine, vol. 56, no. 2, pp. 56-62.

Relationship between pernicious anaemia and gastric neuroendocrine cell disorders. / Spoelstra-de Man, A M; Wagenaar, S S; van der Sluys Veer, A; Brouwer, C B.

In: Netherlands Journal of Medicine, Vol. 56, No. 2, 02.2000, p. 56-62.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Relationship between pernicious anaemia and gastric neuroendocrine cell disorders

AU - Spoelstra-de Man, A M

AU - Wagenaar, S S

AU - van der Sluys Veer, A

AU - Brouwer, C B

PY - 2000/2

Y1 - 2000/2

N2 - The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65%) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise.

AB - The incidence of gastric carcinoid tumours is increasing. This rise is probably due to the number of gastroscopies and improved histological techniques. The majority (65%) of these gastric tumours is associated with chronic atrophic gastritis and pernicious anaemia. In this article two patients are presented, one with pernicious anaemia and gastric neuroendocrine cell hyperplasia and one with pernicious anaemia and multiple gastric carcinoids. These neuroendocrine cell disorders have a relatively favourable prognosis. Therefore, a wait-and-see policy was preferred. The pathogenesis, clinical symptoms, diagnosis, prognosis and treatment of these different neuroendocrine cell manifestations are discussed. We recommend performing a gastroscopy at the time of diagnosis for young patients with pernicious anaemia, and whenever abdominal problems, unexplained weight loss or aggravation of the anaemia arise.

KW - Aged

KW - Aged, 80 and over

KW - Anemia, Pernicious/etiology

KW - Carcinoid Tumor/complications

KW - Enterochromaffin-like Cells/pathology

KW - Gastric Mucosa/pathology

KW - Gastritis, Atrophic/complications

KW - Humans

KW - Male

KW - Stomach Neoplasms/complications

M3 - Review article

VL - 56

SP - 56

EP - 62

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

SN - 0300-2977

IS - 2

ER -