TY - JOUR
T1 - Relief of symptoms and quality of life after conservative versus surgical treatment of benign liver tumors (CONSULT)
T2 - a retrospective propensity score matched study
AU - Furumaya, Alicia
AU - van Rosmalen, Belle V.
AU - de Graeff, Jan Jaap
AU - van der Poel, Marcel J.
AU - Ramsoekh, D. Sandjai
AU - Kazemier, Geert
AU - Verheij, Joanne
AU - Takkenberg, R. Bart
AU - Besselink, Marc G.
AU - Erdmann, Joris I.
AU - van Gulik, Thomas M.
N1 - Funding Information:
This work was supported by the Amsterdam UMC, location AMC [MD/PhD scholarship awarded to B.V. van Rosmalen and A. Furumaya]. The funding source had no involvement in study design, collection, analysis and interpretation of data, writing of the report, or in the decision to submit the article for publication.
Publisher Copyright:
© 2023
PY - 2023
Y1 - 2023
N2 - Background: Surgery can be considered for selected patients with benign liver tumours (BLT). The aim of this study was to compare symptoms and quality of life (QoL) after conservative and surgical management of BLT. Methods: In this dual-site cross-sectional retrospective study, adult patients with BLT diagnosed between 2000 and 2019 completed EORTC QLQ-C30 questionnaires on current symptoms and symptoms at diagnosis. Summary scores (SumScores) and QoL scores at follow-up were compared between surgically and conservatively treated patients by matched t-tests. Propensity score matching attempted to reduce confounding. Higher scores indicate less symptoms and higher QoL. Results: Fifty surgically (22.6%) and 171 (77.4%) conservatively treated patients were included at median 95 (IQR:66–120) and 91 (IQR:52–129) months, respectively. Most surgically treated patients reported stable, improved or disappeared symptoms (87%) and would undergo surgery again (94%). After propensity score matching, surgical patients had higher SumScores (mean difference 9.2, 95%CI:1.0–17.4, p = 0.028) but not higher QoL scores (p = 0.331) at follow-up than conservatively treated counterparts (31 patients in both groups). Discussion: Patients who had undergone surgery often reported they would undergo surgery again. Moreover, they had less symptoms than conservatively managed patients while they were propensity score matched on relevant variables, including baseline symptoms.
AB - Background: Surgery can be considered for selected patients with benign liver tumours (BLT). The aim of this study was to compare symptoms and quality of life (QoL) after conservative and surgical management of BLT. Methods: In this dual-site cross-sectional retrospective study, adult patients with BLT diagnosed between 2000 and 2019 completed EORTC QLQ-C30 questionnaires on current symptoms and symptoms at diagnosis. Summary scores (SumScores) and QoL scores at follow-up were compared between surgically and conservatively treated patients by matched t-tests. Propensity score matching attempted to reduce confounding. Higher scores indicate less symptoms and higher QoL. Results: Fifty surgically (22.6%) and 171 (77.4%) conservatively treated patients were included at median 95 (IQR:66–120) and 91 (IQR:52–129) months, respectively. Most surgically treated patients reported stable, improved or disappeared symptoms (87%) and would undergo surgery again (94%). After propensity score matching, surgical patients had higher SumScores (mean difference 9.2, 95%CI:1.0–17.4, p = 0.028) but not higher QoL scores (p = 0.331) at follow-up than conservatively treated counterparts (31 patients in both groups). Discussion: Patients who had undergone surgery often reported they would undergo surgery again. Moreover, they had less symptoms than conservatively managed patients while they were propensity score matched on relevant variables, including baseline symptoms.
UR - http://www.scopus.com/inward/record.url?scp=85151463437&partnerID=8YFLogxK
U2 - 10.1016/j.hpb.2023.02.019
DO - 10.1016/j.hpb.2023.02.019
M3 - Article
C2 - 36990916
SN - 1477-2574
VL - 25
JO - HPB
JF - HPB
IS - 6
ER -