Renewal timing of long‐acting depot luteinizing hormone‐releasing hormone agonist (Zoladex) is critical in the treatment of hormone‐dependent rat prostatic carcinoma (R3327‐H)

A. A. Geldof, H. J. De Voogt, B. R. Rao

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The effects of luteinizing hormone‐releasing hormone (LHRH) agonist (Zoladex) treatment on hormone‐dependent rat prostate adenocarcinoma (R3327‐H) were investigated based on changes in tumor volume and histology. Tumor‐bearing rats were treated for 10 weeks with Zoladex in depot preparation by implantation every 2, 4, or 6 weeks. Tumor growth rate was similar in the castrated group and in the rats treated every 2 weeks with Zoladex. This growth rate was significantly slower than in animals treated with Zoladex every 6 weeks and the nontreated group. The growth rate in rats treated every 4 weeks appeared to be faster than that in the castrated animals (not significant). Changes in testosterone levels measured during Zoladex treatment correlated with tumor growth kinetics. Zoladex implantation yields effective and complete androgen deprivation only in the rats with two weekly depot renewal regimen. Tumor histology indicated that the stromal as well as the glandular epithelial cells responded to both castration and to Zoladex treatment. However, in tumors from rats treated with Zoladex every 4 and 6 weeks progressive increasing signs of restoration of normal elements, comparable to non‐treated tumors were observed. These results strongly suggest that careful attention has to be paid to the timing of LHRH depot renewal in prostate cancer treatment.

Original languageEnglish
Pages (from-to)281-290
Number of pages10
JournalThe Prostate
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Jan 1987

Cite this

@article{d6273b8f42234edf82ff38bb409d9938,
title = "Renewal timing of long‐acting depot luteinizing hormone‐releasing hormone agonist (Zoladex) is critical in the treatment of hormone‐dependent rat prostatic carcinoma (R3327‐H)",
abstract = "The effects of luteinizing hormone‐releasing hormone (LHRH) agonist (Zoladex) treatment on hormone‐dependent rat prostate adenocarcinoma (R3327‐H) were investigated based on changes in tumor volume and histology. Tumor‐bearing rats were treated for 10 weeks with Zoladex in depot preparation by implantation every 2, 4, or 6 weeks. Tumor growth rate was similar in the castrated group and in the rats treated every 2 weeks with Zoladex. This growth rate was significantly slower than in animals treated with Zoladex every 6 weeks and the nontreated group. The growth rate in rats treated every 4 weeks appeared to be faster than that in the castrated animals (not significant). Changes in testosterone levels measured during Zoladex treatment correlated with tumor growth kinetics. Zoladex implantation yields effective and complete androgen deprivation only in the rats with two weekly depot renewal regimen. Tumor histology indicated that the stromal as well as the glandular epithelial cells responded to both castration and to Zoladex treatment. However, in tumors from rats treated with Zoladex every 4 and 6 weeks progressive increasing signs of restoration of normal elements, comparable to non‐treated tumors were observed. These results strongly suggest that careful attention has to be paid to the timing of LHRH depot renewal in prostate cancer treatment.",
keywords = "androgen deprivation, growth kinetics, histology changes, prostatic tumor",
author = "Geldof, {A. A.} and {De Voogt}, {H. J.} and Rao, {B. R.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1002/pros.2990110308",
language = "English",
volume = "11",
pages = "281--290",
journal = "Prostate",
issn = "0270-4137",
publisher = "Wiley-Liss Inc.",
number = "3",

}

Renewal timing of long‐acting depot luteinizing hormone‐releasing hormone agonist (Zoladex) is critical in the treatment of hormone‐dependent rat prostatic carcinoma (R3327‐H). / Geldof, A. A.; De Voogt, H. J.; Rao, B. R.

In: The Prostate, Vol. 11, No. 3, 01.01.1987, p. 281-290.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Renewal timing of long‐acting depot luteinizing hormone‐releasing hormone agonist (Zoladex) is critical in the treatment of hormone‐dependent rat prostatic carcinoma (R3327‐H)

AU - Geldof, A. A.

AU - De Voogt, H. J.

AU - Rao, B. R.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - The effects of luteinizing hormone‐releasing hormone (LHRH) agonist (Zoladex) treatment on hormone‐dependent rat prostate adenocarcinoma (R3327‐H) were investigated based on changes in tumor volume and histology. Tumor‐bearing rats were treated for 10 weeks with Zoladex in depot preparation by implantation every 2, 4, or 6 weeks. Tumor growth rate was similar in the castrated group and in the rats treated every 2 weeks with Zoladex. This growth rate was significantly slower than in animals treated with Zoladex every 6 weeks and the nontreated group. The growth rate in rats treated every 4 weeks appeared to be faster than that in the castrated animals (not significant). Changes in testosterone levels measured during Zoladex treatment correlated with tumor growth kinetics. Zoladex implantation yields effective and complete androgen deprivation only in the rats with two weekly depot renewal regimen. Tumor histology indicated that the stromal as well as the glandular epithelial cells responded to both castration and to Zoladex treatment. However, in tumors from rats treated with Zoladex every 4 and 6 weeks progressive increasing signs of restoration of normal elements, comparable to non‐treated tumors were observed. These results strongly suggest that careful attention has to be paid to the timing of LHRH depot renewal in prostate cancer treatment.

AB - The effects of luteinizing hormone‐releasing hormone (LHRH) agonist (Zoladex) treatment on hormone‐dependent rat prostate adenocarcinoma (R3327‐H) were investigated based on changes in tumor volume and histology. Tumor‐bearing rats were treated for 10 weeks with Zoladex in depot preparation by implantation every 2, 4, or 6 weeks. Tumor growth rate was similar in the castrated group and in the rats treated every 2 weeks with Zoladex. This growth rate was significantly slower than in animals treated with Zoladex every 6 weeks and the nontreated group. The growth rate in rats treated every 4 weeks appeared to be faster than that in the castrated animals (not significant). Changes in testosterone levels measured during Zoladex treatment correlated with tumor growth kinetics. Zoladex implantation yields effective and complete androgen deprivation only in the rats with two weekly depot renewal regimen. Tumor histology indicated that the stromal as well as the glandular epithelial cells responded to both castration and to Zoladex treatment. However, in tumors from rats treated with Zoladex every 4 and 6 weeks progressive increasing signs of restoration of normal elements, comparable to non‐treated tumors were observed. These results strongly suggest that careful attention has to be paid to the timing of LHRH depot renewal in prostate cancer treatment.

KW - androgen deprivation

KW - growth kinetics

KW - histology changes

KW - prostatic tumor

UR - http://www.scopus.com/inward/record.url?scp=0023500790&partnerID=8YFLogxK

U2 - 10.1002/pros.2990110308

DO - 10.1002/pros.2990110308

M3 - Article

VL - 11

SP - 281

EP - 290

JO - Prostate

JF - Prostate

SN - 0270-4137

IS - 3

ER -