Reported pertussis infection and risk of atopy in 8- to 12-yr-old vaccinated and non-vaccinated children

Roos M D Bernsen, Nico J D Nagelkerke, Carel Thijs, Johannes C van der Wouden

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) = 2.24, 95% confidence interval (CI(95%)): 1.36-3.70], hay fever (OR = 2.35, CI(95%): 1.46-3.77) and food allergy (OR = 2.68, CI(95%): 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalPediatric and Allergy Immunology
Volume19
Issue number1
DOIs
Publication statusPublished - Feb 2008

Cite this

@article{bccfcd7ec7f24584a756dc9fcde04c9d,
title = "Reported pertussis infection and risk of atopy in 8- to 12-yr-old vaccinated and non-vaccinated children",
abstract = "Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) = 2.24, 95{\%} confidence interval (CI(95{\%})): 1.36-3.70], hay fever (OR = 2.35, CI(95{\%}): 1.46-3.77) and food allergy (OR = 2.68, CI(95{\%}): 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation.",
keywords = "Child, Female, Humans, Hypersensitivity/epidemiology, Male, Pertussis Vaccine/immunology, Prevalence, Risk, Vaccination, Whooping Cough/complications",
author = "Bernsen, {Roos M D} and Nagelkerke, {Nico J D} and Carel Thijs and {van der Wouden}, {Johannes C}",
year = "2008",
month = "2",
doi = "10.1111/j.1399-3038.2007.00584.x",
language = "English",
volume = "19",
pages = "46--52",
journal = "Pediatric and Allergy Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "1",

}

Reported pertussis infection and risk of atopy in 8- to 12-yr-old vaccinated and non-vaccinated children. / Bernsen, Roos M D; Nagelkerke, Nico J D; Thijs, Carel; van der Wouden, Johannes C.

In: Pediatric and Allergy Immunology, Vol. 19, No. 1, 02.2008, p. 46-52.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Reported pertussis infection and risk of atopy in 8- to 12-yr-old vaccinated and non-vaccinated children

AU - Bernsen, Roos M D

AU - Nagelkerke, Nico J D

AU - Thijs, Carel

AU - van der Wouden, Johannes C

PY - 2008/2

Y1 - 2008/2

N2 - Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) = 2.24, 95% confidence interval (CI(95%)): 1.36-3.70], hay fever (OR = 2.35, CI(95%): 1.46-3.77) and food allergy (OR = 2.68, CI(95%): 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation.

AB - Pertussis infection has been suspected to be a potential causal factor in the development of atopic disease because of the effect of pertussis immunization on specific IgE antibodies. Although several studies found a positive association between pertussis infection and atopic disorders, this relationship has not yet been studied in a population stratified by vaccination status. To assess the association between pertussis infection and atopic disorders in pertussis-unvaccinated children and in pertussis-vaccinated children. Using data from a previously conducted study on the relationship between the diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination in the first year of life and atopic disorders, the study population of 1872 8-12 yr old was divided into children pertussis-unvaccinated and children pertussis-vaccinated in the first year of life. Within each group, the association between pertussis infection and atopic disorders (both as reported by the parents) was assessed. In the unvaccinated group, there were no significant associations between pertussis infection and atopic disorders. In the vaccinated group, all associations between pertussis infection and atopic disorders were positive, the associations with asthma [odds ratio (OR) = 2.24, 95% confidence interval (CI(95%)): 1.36-3.70], hay fever (OR = 2.35, CI(95%): 1.46-3.77) and food allergy (OR = 2.68, CI(95%): 1.48-4.85) being significant. There was a positive association between pertussis infection and atopic disorders in the pertussis vaccinated group only. From the present study, it cannot be concluded whether this association is causal or due to reverse causation.

KW - Child

KW - Female

KW - Humans

KW - Hypersensitivity/epidemiology

KW - Male

KW - Pertussis Vaccine/immunology

KW - Prevalence

KW - Risk

KW - Vaccination

KW - Whooping Cough/complications

U2 - 10.1111/j.1399-3038.2007.00584.x

DO - 10.1111/j.1399-3038.2007.00584.x

M3 - Article

VL - 19

SP - 46

EP - 52

JO - Pediatric and Allergy Immunology

JF - Pediatric and Allergy Immunology

SN - 0905-6157

IS - 1

ER -