Abstract
For the detection and quantification of residual solvents in solutions of radiopharmaceuticals for human applications, a new analysis method was set up. With a simple direct gas chromatography injection, no special sample treatments or special injection techniques (such as head-space or solid-phase microextraction) are necessary. This method is especially suited for the fast and quantitative analysis of residual solvents in radiopharmaceutical formulations where 5-12% ethanol is present. The method proved to be both accurate and linear. The quantification limit is in the lower parts-per-million range, which is sufficient given the need for a fast analysis and the maximally allowed concentration for these residual solvents.
Original language | English |
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Pages (from-to) | 935-938 |
Number of pages | 4 |
Journal | Nuclear Medicine and Biology |
Volume | 33 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1 Oct 2006 |