Abstract
Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.
| Original language | English |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | Seminars in Dialysis |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 25 Jan 2005 |
Cite this
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Resolving controversies regarding hemodiafiltration versus hemodialysis : the Dutch Convective Transport Study. / CONTRAST Group.
In: Seminars in Dialysis, Vol. 18, No. 1, 25.01.2005, p. 47-51.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Resolving controversies regarding hemodiafiltration versus hemodialysis
T2 - the Dutch Convective Transport Study
AU - CONTRAST Group
AU - Penne, E Lars
AU - Blankestijn, Peter J
AU - Bots, Michiel L
AU - van den Dorpel, Marinus A
AU - Grooteman, Muriel P C
AU - Nubé, Menso J
AU - ter Wee, Piet M
PY - 2005/1/25
Y1 - 2005/1/25
N2 - Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.
AB - Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.
KW - Hemodiafiltration/methods
KW - Humans
KW - Kidney Failure, Chronic/metabolism
KW - Netherlands
KW - Randomized Controlled Trials as Topic
KW - Renal Dialysis/methods
KW - Toxins, Biological/metabolism
KW - Treatment Outcome
U2 - 10.1111/j.1525-139X.2005.18107.x
DO - 10.1111/j.1525-139X.2005.18107.x
M3 - Review article
VL - 18
SP - 47
EP - 51
JO - Seminars in Dialysis
JF - Seminars in Dialysis
SN - 0894-0959
IS - 1
ER -