Resolving controversies regarding hemodiafiltration versus hemodialysis: the Dutch Convective Transport Study

CONTRAST Group

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalSeminars in Dialysis
Volume18
Issue number1
DOIs
Publication statusPublished - 25 Jan 2005

Cite this

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title = "Resolving controversies regarding hemodiafiltration versus hemodialysis: the Dutch Convective Transport Study",
abstract = "Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.",
keywords = "Hemodiafiltration/methods, Humans, Kidney Failure, Chronic/metabolism, Netherlands, Randomized Controlled Trials as Topic, Renal Dialysis/methods, Toxins, Biological/metabolism, Treatment Outcome",
author = "{CONTRAST Group} and Penne, {E Lars} and Blankestijn, {Peter J} and Bots, {Michiel L} and {van den Dorpel}, {Marinus A} and Grooteman, {Muriel P C} and Nub{\'e}, {Menso J} and {ter Wee}, {Piet M}",
year = "2005",
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language = "English",
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}

Resolving controversies regarding hemodiafiltration versus hemodialysis : the Dutch Convective Transport Study. / CONTRAST Group.

In: Seminars in Dialysis, Vol. 18, No. 1, 25.01.2005, p. 47-51.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Resolving controversies regarding hemodiafiltration versus hemodialysis

T2 - the Dutch Convective Transport Study

AU - CONTRAST Group

AU - Penne, E Lars

AU - Blankestijn, Peter J

AU - Bots, Michiel L

AU - van den Dorpel, Marinus A

AU - Grooteman, Muriel P C

AU - Nubé, Menso J

AU - ter Wee, Piet M

PY - 2005/1/25

Y1 - 2005/1/25

N2 - Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.

AB - Hemodialysis patients suffer from a high incidence of cardiovascular disease. Among the many predisposing factors, such as high blood pressure, dyslipidemia, and fluid overload, the accumulation of high molecular weight uremic toxins, the so-called middle molecules, may play an important role. Since convective therapies such as online hemodiafiltration have a better clearance profile for these compounds than standard hemodialysis, it has been suggested that these dialysis strategies may reduce cardiovascular morbidity and mortality. As reliable data on these issues are not available, the Dutch Convective Transport Study (CONTRAST) was recently initiated. This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality.

KW - Hemodiafiltration/methods

KW - Humans

KW - Kidney Failure, Chronic/metabolism

KW - Netherlands

KW - Randomized Controlled Trials as Topic

KW - Renal Dialysis/methods

KW - Toxins, Biological/metabolism

KW - Treatment Outcome

U2 - 10.1111/j.1525-139X.2005.18107.x

DO - 10.1111/j.1525-139X.2005.18107.x

M3 - Review article

VL - 18

SP - 47

EP - 51

JO - Seminars in Dialysis

JF - Seminars in Dialysis

SN - 0894-0959

IS - 1

ER -