Rest-activity patterns in patients with delirium

Miranda Van Uitert*, Annemarieke De Jonghe, Swana De Gijsel, Eus J.W. Van Someren, Sophia E.J.A. De Rooij, Barbara C. Van Munster

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: Delirium is a frequent syndrome in elderly hospital patients. Symptoms typically show a fluctuating course during the day, with patients exhibiting disturbances of their sleep-wake rhythm. Delirium is frequently underdiagnosed, especially the so-called hypoactive subtype. Devices measuring 24-hr motor patterns could contribute to the recognition of delirium. The purpose of this paper is two-fold. First, the results of a pilot study are presented, in which 24-hr motor patterns of delirious patients are measured with a wrist-actigraph. Second, studies reporting 24-hr motor patterns in delirious patients are systematically reviewed. Methods: The pilot study included 9 patients, 65 years or older, with a hip fracture in need of surgical repair. For the review, MEDLINE and Embase were searched for studies on motor activity assessment in delirious patients. Results: In the pilot study, the 24-hr activity rhythm was severely disturbed during delirium, and most actigraphic sleep parameter estimates indicated significantly worse sleep during delirious nights. The systematic search resulted in 10 papers. In 3 papers, the sleep-wake rhythm of delirious patients was significantly different from that of nondelirious patients. In 5 papers, delirious patients could be classified into delirium subtypes. In the 2 remaining papers, 24-hr motor patterns of delirium subtypes were not significantly different. Conclusion: Activity patterns revealed differences between delirious and nondelirious patients and between the different subtypes, even in small samples of patients. Future studies, with preferably larger sample sizes, should confirm the potential of activity pattern measuring devices in the early detection of delirium.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalRejuvenation Research
Volume14
Issue number5
DOIs
Publication statusPublished - 1 Oct 2011

Cite this

Van Uitert, M., De Jonghe, A., De Gijsel, S., Van Someren, E. J. W., De Rooij, S. E. J. A., & Van Munster, B. C. (2011). Rest-activity patterns in patients with delirium. Rejuvenation Research, 14(5), 483-490. https://doi.org/10.1089/rej.2011.1181