Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect

Rodolfo Llinás; Francisco J. Urbano; Elena Leznik; Rey R. Ramírez; Hein J F Van Marle

doi:10.1016/j.tins.2005.04.006

Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect

Rodolfo Llinás, Francisco J. Urbano, Elena Leznik, Rey R. Ramírez, Hein J F Van Marle

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Brain function is fundamentally related in the most general sense to the richness of thalamocortical interconnectivity, and in particular to the rhythmic oscillatory properties of thalamocortical loops. Such rhythmicity is involved in the genesis of cognition, in the sleep-wake cycle, and in several neurological and psychiatric disorders. The role of GABA-mediated transmission in regulating these functional states is addressed here. At the cortical level, inhibition determines the spread of cortical activation by sculpting the precise activity patterns that underlie the details of cognition and motor control. At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	325-333
Number of pages	9
Journal	Trends in Neurosciences
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/j.tins.2005.04.006
Publication status	Published - Jun 2005
Externally published	Yes

Access to Document

10.1016/j.tins.2005.04.006

http://www.mendeley.com/research/rhythmic-dysrhythmic-thalamocortical-dynamics-gaba-systems-edge-effect

Cite this

Llinás, R., Urbano, F. J., Leznik, E., Ramírez, R. R., & Van Marle, H. J. F. (2005). Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends in Neurosciences, 28(6), 325-333. https://doi.org/10.1016/j.tins.2005.04.006

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abstract = "Brain function is fundamentally related in the most general sense to the richness of thalamocortical interconnectivity, and in particular to the rhythmic oscillatory properties of thalamocortical loops. Such rhythmicity is involved in the genesis of cognition, in the sleep-wake cycle, and in several neurological and psychiatric disorders. The role of GABA-mediated transmission in regulating these functional states is addressed here. At the cortical level, inhibition determines the spread of cortical activation by sculpting the precise activity patterns that underlie the details of cognition and motor control. At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels. {\circledC} 2005 Elsevier Ltd. All rights reserved.",

author = "Rodolfo Llin{\'a}s and Urbano, {Francisco J.} and Elena Leznik and Ram{\'i}rez, {Rey R.} and {Van Marle}, {Hein J F}",

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T2 - GABA systems and the edge effect

AU - Llinás, Rodolfo

AU - Urbano, Francisco J.

AU - Leznik, Elena

AU - Ramírez, Rey R.

AU - Van Marle, Hein J F

PY - 2005/6

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AB - Brain function is fundamentally related in the most general sense to the richness of thalamocortical interconnectivity, and in particular to the rhythmic oscillatory properties of thalamocortical loops. Such rhythmicity is involved in the genesis of cognition, in the sleep-wake cycle, and in several neurological and psychiatric disorders. The role of GABA-mediated transmission in regulating these functional states is addressed here. At the cortical level, inhibition determines the spread of cortical activation by sculpting the precise activity patterns that underlie the details of cognition and motor control. At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels. © 2005 Elsevier Ltd. All rights reserved.

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