TY - JOUR
T1 - Rhythmic and dysrhythmic thalamocortical dynamics
T2 - GABA systems and the edge effect
AU - Llinás, Rodolfo
AU - Urbano, Francisco J.
AU - Leznik, Elena
AU - Ramírez, Rey R.
AU - Van Marle, Hein J F
PY - 2005/6
Y1 - 2005/6
N2 - Brain function is fundamentally related in the most general sense to the richness of thalamocortical interconnectivity, and in particular to the rhythmic oscillatory properties of thalamocortical loops. Such rhythmicity is involved in the genesis of cognition, in the sleep-wake cycle, and in several neurological and psychiatric disorders. The role of GABA-mediated transmission in regulating these functional states is addressed here. At the cortical level, inhibition determines the spread of cortical activation by sculpting the precise activity patterns that underlie the details of cognition and motor control. At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels. © 2005 Elsevier Ltd. All rights reserved.
AB - Brain function is fundamentally related in the most general sense to the richness of thalamocortical interconnectivity, and in particular to the rhythmic oscillatory properties of thalamocortical loops. Such rhythmicity is involved in the genesis of cognition, in the sleep-wake cycle, and in several neurological and psychiatric disorders. The role of GABA-mediated transmission in regulating these functional states is addressed here. At the cortical level, inhibition determines the spread of cortical activation by sculpting the precise activity patterns that underlie the details of cognition and motor control. At the thalamic level, GABA-mediated inhibition modulates and resets distribution of the ongoing thalamocortical rhythmic oscillations that bind multisensory inputs into a single cognitive experience and regulate arousal levels. © 2005 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.tins.2005.04.006
DO - 10.1016/j.tins.2005.04.006
M3 - Article
C2 - 15927689
VL - 28
SP - 325
EP - 333
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0166-2236
IS - 6
ER -