Rickets and osteomalacia

Michaël R. Laurent, Nathalie Bravenboer, Natasja M. Van Schoor, Roger Bouillon, John M. Pettifor, Paul Lips

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

This chapter describes definition, etiology, pathophysiology, diagnosis, treatment and prevention of nutritional rickets and osteomalacia. Rickets and osteomalacia (from Greek osteon and malakia, bone softness) are diseases characterized by hypomineralization of bone matrix. Rickets occurs only in children (before epiphyseal closure) and additionally leads to abnormal growth plate development, stunting, and bone deformities. The causes of osteomalacia and rickets are similar and can be classified according to underlying mechanisms: Vitamin D deficiency or resistance; calcium deficiency independent of vitamin D; hypophosphatemic disorders; and mineralization inhibitors. Patients with rickets and osteomalacia related to vitamin D deficiency typically have very low serum 250-hydroxyvitamin D (25OHD) concentrations, that is below 15 to 30?nmol/L. Vitamin D deficiency rickets responds to small doses of vitamin D. Nutritional osteomalacia may be treated with remarkably low doses of calcium and vitamin D.

Original languageEnglish
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
PublisherWiley
Pages684-694
Number of pages11
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
DOIs
Publication statusPublished - 1 Jan 2018

Cite this

Laurent, M. R., Bravenboer, N., Van Schoor, N. M., Bouillon, R., Pettifor, J. M., & Lips, P. (2018). Rickets and osteomalacia. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 684-694). Wiley. https://doi.org/10.1002/9781119266594.ch89