Right ventricle in pulmonary hypertension

Norbert F Voelkel, Ramesh Natarajan, Jennifer I Drake, Herman J Bogaard

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

During heart development chamber specification is controlled and directed by a number of genes and a fetal heart gene expression pattern is revisited during heart failure. In the setting of chronic pulmonary hypertension the right ventricle undergoes hypertrophy, which is likely initially adaptive, but often followed by decompensation, dilatation and failure. Here we discuss differences between the right ventricle and the left ventricle of the heart and begin to describe the cellular and molecular changes which characterize right heart failure. A prevention and treatment of right ventricle failure becomes a treatment goal for patients with severe pulmonary hypertension it follows that we need to understand the pathobiology of right heart hypertrophy and the transition to right heart failure.

Original languageEnglish
Pages (from-to)525-40
Number of pages16
JournalComprehensive Physiology
Volume1
Issue number1
DOIs
Publication statusPublished - Jan 2011

Cite this

Voelkel, Norbert F ; Natarajan, Ramesh ; Drake, Jennifer I ; Bogaard, Herman J. / Right ventricle in pulmonary hypertension. In: Comprehensive Physiology. 2011 ; Vol. 1, No. 1. pp. 525-40.
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Right ventricle in pulmonary hypertension. / Voelkel, Norbert F; Natarajan, Ramesh; Drake, Jennifer I; Bogaard, Herman J.

In: Comprehensive Physiology, Vol. 1, No. 1, 01.2011, p. 525-40.

Research output: Contribution to journalReview articleAcademicpeer-review

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AU - Voelkel, Norbert F

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AB - During heart development chamber specification is controlled and directed by a number of genes and a fetal heart gene expression pattern is revisited during heart failure. In the setting of chronic pulmonary hypertension the right ventricle undergoes hypertrophy, which is likely initially adaptive, but often followed by decompensation, dilatation and failure. Here we discuss differences between the right ventricle and the left ventricle of the heart and begin to describe the cellular and molecular changes which characterize right heart failure. A prevention and treatment of right ventricle failure becomes a treatment goal for patients with severe pulmonary hypertension it follows that we need to understand the pathobiology of right heart hypertrophy and the transition to right heart failure.

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KW - Atrial Natriuretic Factor/physiology

KW - Disease Models, Animal

KW - Disease Progression

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