TY - JOUR
T1 - Right Ventricular and Right Atrial Function Are Less Compromised in Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction
T2 - A Comparison With Pulmonary Arterial Hypertension With Similar Pressure Overload
AU - van Wezenbeek, Jessie
AU - Kianzad, Azar
AU - van de Bovenkamp, Arno
AU - Wessels, Jeroen
AU - Mouratoglou, Sophia A.
AU - Braams, Natalia J.
AU - Jansen, Samara M.A.
AU - Meulblok, Eva
AU - Meijboom, Lilian J.
AU - Marcus, J. Tim
AU - Vonk Noordegraaf, Anton
AU - José Goumans, Marie
AU - Jan Bogaard, Harm
AU - Handoko, M. Louis
AU - de Man, Frances S.
N1 - Funding Information:
This research was financially supported by the Netherlands Organization for Scientific Research: NWO-VICI No. 918.16.610 (Dr Vonk Noordegraaf) and NWO-VIDI No. 917.18.338 (Dr de Man). The work was also funded by Dutch Heart Foundation Dekker senior post doctorate grant No. 2018T059 (J. van Wezenbeek and Dr de Man), Dekker Senior Clinical Scientist grant No. 2020T058 (Dr Handoko), and the Netherlands CardioVascular Research Initiative: CVON-2017-10 DOLPHIN-GENESIS (Drs Vonk Noordegraaf, de Man, Jan Bogaard, and José Goumans) and CVON-2018-29 PHAEDRA-IMPACT (Drs Vonk Noordegraaf, de Man, Jan Bogaard, and José Goumans).
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a prevalent disorder for which no effective treatment yet exists. Pulmonary hypertension (PH) and right atrial (RA) and ventricular (RV) dysfunction are frequently observed. The question remains whether the PH with the associated RV/RA dysfunction in HFpEF are markers of disease severity. METHODS: To obtain insight in the relative importance of pressure-overload and left-to-right interaction, we compared RA and RV function in 3 groups: 1. HFpEF (n=13); 2. HFpEF-PH (n=33), and; 3. pulmonary arterial hypertension (PAH) matched to pulmonary artery pressures of HFpEF-PH (PH limited to mPAP ≥30 and ≤50 mmHg) (n=47). Patients underwent right heart catheterization and cardiac magnetic resonance imaging. RESULTS: The right ventricle in HFpEF-PH was less dilated and hypertrophied than in PAH. In addition, RV ejection fraction was more preserved (HFpEF-PH: 52±11 versus PAH: 36±12%). RV filling patterns differed: vena cava backflow during RA contraction was observed in PAH only. In HFpEF-PH, RA pressure was elevated throughout the cardiac cycle (HFpEF-PH: 10 [8-14] versus PAH: 7 [5-10] mm Hg), while RA volume was smaller, reflecting excessive RA stiffness (HFpEF-PH: 0.14 [0.10-0.17] versus PAH: 0.08 [0.06-0.11] mm Hg/mL). RA stiffness was associated with an increased eccentricity index (HFpEF-PH: 1.3±0.2 versus PAH: 1.2±0.1) and interatrial pressure gradient (9 [5 to 12] versus 2 [-2 to 5] mm Hg). CONCLUSIONS: RV/RA function was less compromised in HFpEF-PH than in PAH, despite similar pressure-overload. Increased RA pressure and stiffness in HFpEF-PH were explained by left atrial/RA-interaction. Therefore, our results indicate that increased RA pressure is not a sign of overt RV failure but rather a reflection of HFpEF-severity.
AB - BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a prevalent disorder for which no effective treatment yet exists. Pulmonary hypertension (PH) and right atrial (RA) and ventricular (RV) dysfunction are frequently observed. The question remains whether the PH with the associated RV/RA dysfunction in HFpEF are markers of disease severity. METHODS: To obtain insight in the relative importance of pressure-overload and left-to-right interaction, we compared RA and RV function in 3 groups: 1. HFpEF (n=13); 2. HFpEF-PH (n=33), and; 3. pulmonary arterial hypertension (PAH) matched to pulmonary artery pressures of HFpEF-PH (PH limited to mPAP ≥30 and ≤50 mmHg) (n=47). Patients underwent right heart catheterization and cardiac magnetic resonance imaging. RESULTS: The right ventricle in HFpEF-PH was less dilated and hypertrophied than in PAH. In addition, RV ejection fraction was more preserved (HFpEF-PH: 52±11 versus PAH: 36±12%). RV filling patterns differed: vena cava backflow during RA contraction was observed in PAH only. In HFpEF-PH, RA pressure was elevated throughout the cardiac cycle (HFpEF-PH: 10 [8-14] versus PAH: 7 [5-10] mm Hg), while RA volume was smaller, reflecting excessive RA stiffness (HFpEF-PH: 0.14 [0.10-0.17] versus PAH: 0.08 [0.06-0.11] mm Hg/mL). RA stiffness was associated with an increased eccentricity index (HFpEF-PH: 1.3±0.2 versus PAH: 1.2±0.1) and interatrial pressure gradient (9 [5 to 12] versus 2 [-2 to 5] mm Hg). CONCLUSIONS: RV/RA function was less compromised in HFpEF-PH than in PAH, despite similar pressure-overload. Increased RA pressure and stiffness in HFpEF-PH were explained by left atrial/RA-interaction. Therefore, our results indicate that increased RA pressure is not a sign of overt RV failure but rather a reflection of HFpEF-severity.
KW - heart failure
KW - pulmonary arterial hypertension
KW - right atrium
KW - right ventricle
KW - ventricular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=85124635685&partnerID=8YFLogxK
U2 - 10.1161/CIRCHEARTFAILURE.121.008726
DO - 10.1161/CIRCHEARTFAILURE.121.008726
M3 - Article
C2 - 34937392
SN - 1941-3289
VL - 15
SP - E008726
JO - Circulation. Heart failure
JF - Circulation. Heart failure
IS - 2
ER -