Dwalingen in de methodologie. VIII. Pilotonderzoeken: Zin en onzin

Translated title of the contribution: Roaming through methodology. VIII. Pilot studies: Sense and nonsense

A. J.H.M. Beurskens*, H. C.W. De Vet, Ij Kant

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

- A pilot study is often performed before the start of a large study. Its aim is improving the methodological quality and evaluating the feasibility. - The results of a pilot study are also often used to gain an impression of the efficacy of an intervention. For this purpose a pilot is absolutely unsuited. - However, the estimate of the effect of an intervention in small studies such as pilot studies is determined to a large extent by chance. When conducting small studies the chance of publication bias is large. - Small studies of adequate methodological quality should be published, whether the results are positive or negative, significant or non- significant, because combination in a later cumulative meta-analysis may lead to sufficient power to assess the efficacy of an experimental intervention.

Original languageDutch
Pages (from-to)2142-2145
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Volume142
Issue number39
Publication statusPublished - 26 Sep 1998

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