Role of chemokines in the development of secondary and tertiary lymphoid tissues

Tom Cupedo, Reina E Mebius

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45+CD4+CD3- cells. Hereto CD45+CD4+CD3- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.

Original languageEnglish
Pages (from-to)243-8
Number of pages6
JournalSeminars in immunology
Volume15
Issue number5
DOIs
Publication statusPublished - Oct 2003

Cite this

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title = "Role of chemokines in the development of secondary and tertiary lymphoid tissues",
abstract = "Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45+CD4+CD3- cells. Hereto CD45+CD4+CD3- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.",
keywords = "Animals, Cell Differentiation, Chemokines/immunology, Humans, Inflammation/immunology, Lymphoid Tissue/cytology, Signal Transduction",
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language = "English",
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Role of chemokines in the development of secondary and tertiary lymphoid tissues. / Cupedo, Tom; Mebius, Reina E.

In: Seminars in immunology, Vol. 15, No. 5, 10.2003, p. 243-8.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Role of chemokines in the development of secondary and tertiary lymphoid tissues

AU - Cupedo, Tom

AU - Mebius, Reina E

PY - 2003/10

Y1 - 2003/10

N2 - Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45+CD4+CD3- cells. Hereto CD45+CD4+CD3- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.

AB - Organogenesis of lymph nodes and Peyer's patches is initiated during embryonic development and depends on the correct expression of a wide variety of molecules. Essential for this process is the paracrine triggering of stromal cells by CD45+CD4+CD3- cells. Hereto CD45+CD4+CD3- cells and stromal cells need to be spatially positioned in close proximity to each other. Expression of adhesion molecules and chemokines is thought to be essential for this process. During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions.

KW - Animals

KW - Cell Differentiation

KW - Chemokines/immunology

KW - Humans

KW - Inflammation/immunology

KW - Lymphoid Tissue/cytology

KW - Signal Transduction

U2 - 10.1016/j.smim.2003.08.002

DO - 10.1016/j.smim.2003.08.002

M3 - Review article

VL - 15

SP - 243

EP - 248

JO - Seminars in immunology

JF - Seminars in immunology

SN - 1044-5323

IS - 5

ER -