@article{44393c9432484c3383f28342080cb169,
title = "Salt intake and blood pressure response to percutaneous renal denervation in resistant hypertension",
abstract = "The effect of lowering sympathetic nerve activity by renal denervation (RDN) is highly variable. With the exception of office systolic blood pressure (BP), predictors of the BP-lowering effect have not been identified. Because dietary sodium intake influences sympathetic drive, and, conversely, sympathetic activity influences salt sensitivity in hypertension, we investigated 24-hour urinary sodium excretion in participants of the SYMPATHY trial. SYMPATHY investigated RDN in patients with resistant hypertension. Both 24-hour ambulatory and office BP measurements were end points. No relationship was found for baseline sodium excretion and change in BP 6 months after RDN in multivariable-adjusted regression analysis. Change in the salt intake–measured BP relationships at 6 months vs baseline was used as a measure for salt sensitivity. BP was 8 mm Hg lower with similar salt intake after RDN, suggesting a decrease in salt sensitivity. However, the change was similar in the control group, and thus not attributable to RDN.",
keywords = "dietary sodium, hypertension, renal denervation, salt sensitivity, sodium intake",
author = "{de Beus}, Esther and {de Jager}, {R. L.} and Beeftink, {Martine M.} and Sanders, {Margreet F.} and Wilko Spiering and Vonken, {Evert Jan} and Michiel Voskuil and Bots, {M. L.} and Blankestijn, {P. J.} and O. Elgersma and Ijsselmuiden, {A. J.J.} and {van der Valk}, P.H.M. and {Smak Gregoor}, P. and S. Roodenburg and M. Meuwissen and W. Dewilde and I. Hunze and {den Hollander}, J. and Vincent, {H. H.} and B. Rensing and Bos, {W. J.} and {an Weverwijk}, I. and Tonino, {P. A.L.} and Brueren, {B. R.G.} and Konings, {C. J.A.M.} and Gompel, {H. Hendrix van} and Heeg, {J. E.} and J. Lambert and Smit, {J. J.} and A. lvan and A. Berends and {de Jager}, B. and G. Laverman and {de Vries}, {P. A.M.} and {van Balen}, A. and M. Stoel and R. Steggerda and L. Niamut and W. Bossen and J. Biermann and I. Knot and Peels, {J. O.J.} and {de Swart}, {J. B.} and G. Kimman and W. Bax and K. Parlevliet and {van den Berg}, A. and {de Haan}, M. and Sanders, {M. F.} and J. Deinum and {the SYMPATHY study group}",
year = "2017",
month = "11",
day = "1",
doi = "10.1111/jch.13085",
language = "English",
volume = "19",
pages = "1125--1133",
journal = "Journal of Clinical Hypertension",
issn = "1524-6175",
publisher = "Wiley-Blackwell",
number = "11",
}