Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

Rebecca T. Karsten, Abrahim Al-Mamgani, Sandra I. Bril, Sheena Tjon-A-Joe, Lisette van der Molen, Jan P. de Boer, Frans J. M. Hilgers, Ludi E. Smeele, Michiel W. M. van den Brekel, Martijn M. Stuiver

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency. Methods: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT. Results: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P =.01) adjusted for body mass index, abnormal diet, and socioeconomic status. Conclusions: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.
Original languageEnglish
Pages (from-to)4000-4008
Number of pages9
JournalHead and Neck
Volume41
Issue number11
DOIs
Publication statusPublished - 1 Nov 2019
Externally publishedYes

Cite this

Karsten, R. T., Al-Mamgani, A., Bril, S. I., Tjon-A-Joe, S., van der Molen, L., de Boer, J. P., ... Stuiver, M. M. (2019). Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer. Head and Neck, 41(11), 4000-4008. https://doi.org/10.1002/hed.25938