TY - JOUR
T1 - Screening of chlamydia trachomatis and waddlia chondrophila antibodies in women with tubal factor infertility
AU - van Dooremalen, Wies T. M.
AU - Verweij, Stephan P.
AU - den Hartog, Janneke E.
AU - Kebbi-Beghdadi, Carole
AU - Ouburg, Sander
AU - Greub, Gilbert
AU - Morré, Servaas A.
AU - Ammerdorffer, Anne
N1 - Funding Information:
Funding: Part of this research was supported by or in line with the following projects: Eurostars project SOL-CT (Eureka number E!11539), Globalstars project InPoChlam (Eureka number GS181005 E!13075), H2020-INNOSUP-02-2016 (739679).
Publisher Copyright:
© 2020 by the authors.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Waddlia chondrophila is an emerging intracellular pathogen belonging to the order of Chlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both W. chondrophila and Chlamydia trachomatis IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for C. trachomatis and 38.8% for W. chondrophila. C. trachomatis antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for W. chondrophila no difference could be observed. In conclusion, our study confirms the association between C. trachomatis seropositivity and TFI, but no association was found between W. chondrophila seropositivity and TFI. The high percentage of W. chondrophila seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this Chlamydia-like bacterium and its possible role in infertility.
AB - Waddlia chondrophila is an emerging intracellular pathogen belonging to the order of Chlamydiales, and was previously associated with adverse pregnancy outcomes, as well as tubal factor infertility (TFI). In this study, we investigate the link between both W. chondrophila and Chlamydia trachomatis IgG seropositivity and TFI. Antibodies against both bacteria were measured in 890 serum samples of women visiting a fertility clinic. After a hysterosalpingography and/or laparoscopy, they were classified as either TFI-negative (TFI−) or TFI-positive (TFI+). The total seroprevalence was 13.4% for C. trachomatis and 38.8% for W. chondrophila. C. trachomatis antibodies were present significantly more often in the TFI+ group than in the TFI− group, while for W. chondrophila no difference could be observed. In conclusion, our study confirms the association between C. trachomatis seropositivity and TFI, but no association was found between W. chondrophila seropositivity and TFI. The high percentage of W. chondrophila seropositivity in all women attending a fertility clinic does, however, demonstrate the need for further research on this Chlamydia-like bacterium and its possible role in infertility.
KW - Chlamydia trachomatis
KW - Female reproductive health
KW - Serology
KW - Tubal factor infertility
KW - Waddlia chondrophila
UR - http://www.scopus.com/inward/record.url?scp=85090707262&partnerID=8YFLogxK
U2 - 10.3390/microorganisms8060918
DO - 10.3390/microorganisms8060918
M3 - Article
C2 - 32560559
VL - 8
SP - 1
EP - 9
JO - Microorganisms
JF - Microorganisms
SN - 2076-2607
IS - 6
M1 - 918
ER -