Self- and nonself-recognition by C-type lectins on dendritic cells

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that collect antigen in body tissues and transport them to draining lymph nodes. Antigenic peptides are loaded onto major histocompatibility complex (MHC) molecules for presentation to naive T cells, resulting in the induction of cellular and humoral immune responses. DCs take up antigen through phagocytosis, pinocytosis, and endocytosis via different groups of receptor families, such as Fc receptors for antigen-antibody complexes, C-type lectin receptors (CLRs) for glycoproteins, and pattern recognition receptors, such as Toll-like receptors (TLRs), for microbial antigens. Uptake of antigen by CLRs leads to presentation of antigens on MHC class I and II molecules. DCs are well equipped to distinguish between self- and nonself-antigens by the variable expression of cell-surface receptors such as CLRs and TLRs. In the steady state, DCs are not immunologically quiescent but use their antigen-handling capacities to maintain peripheral tolerance. DCs are continuously sampling and presenting self- and harmless environmental proteins to silence immune activation. Uptake of self-components in the intestine and airways are good examples of sites where continuous presentation of self- and foreign antigens occurs without immune activation. In contrast, efficient antigen-specific immune activation occurs upon encounter of DCs with nonself-pathogens. Recognition of pathogens by DCs triggers specific receptors such as TLRs that result in DC maturation and subsequently immune activation. Here we discuss the concept that cross talk between TLRs and CLRs, differentially expressed by subsets of DCs, accounts for the different pathways to peripheral tolerance, such as deletion and suppression, and immune activation.

Original languageEnglish
Pages (from-to)33-54
Number of pages22
JournalAnnual Review of Immunology
Volume22
DOIs
Publication statusPublished - 2004

Cite this

@article{9473cc80eebf4640a953ef452b530cb5,
title = "Self- and nonself-recognition by C-type lectins on dendritic cells",
abstract = "Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that collect antigen in body tissues and transport them to draining lymph nodes. Antigenic peptides are loaded onto major histocompatibility complex (MHC) molecules for presentation to naive T cells, resulting in the induction of cellular and humoral immune responses. DCs take up antigen through phagocytosis, pinocytosis, and endocytosis via different groups of receptor families, such as Fc receptors for antigen-antibody complexes, C-type lectin receptors (CLRs) for glycoproteins, and pattern recognition receptors, such as Toll-like receptors (TLRs), for microbial antigens. Uptake of antigen by CLRs leads to presentation of antigens on MHC class I and II molecules. DCs are well equipped to distinguish between self- and nonself-antigens by the variable expression of cell-surface receptors such as CLRs and TLRs. In the steady state, DCs are not immunologically quiescent but use their antigen-handling capacities to maintain peripheral tolerance. DCs are continuously sampling and presenting self- and harmless environmental proteins to silence immune activation. Uptake of self-components in the intestine and airways are good examples of sites where continuous presentation of self- and foreign antigens occurs without immune activation. In contrast, efficient antigen-specific immune activation occurs upon encounter of DCs with nonself-pathogens. Recognition of pathogens by DCs triggers specific receptors such as TLRs that result in DC maturation and subsequently immune activation. Here we discuss the concept that cross talk between TLRs and CLRs, differentially expressed by subsets of DCs, accounts for the different pathways to peripheral tolerance, such as deletion and suppression, and immune activation.",
keywords = "Animals, Antigen Presentation/immunology, Cell Communication/immunology, Dendritic Cells/immunology, Humans, Lectins, C-Type/immunology, Lymphocyte Activation/immunology, Membrane Glycoproteins/immunology, Receptors, Cell Surface/immunology, Self Tolerance/immunology, Signal Transduction/immunology, Toll-Like Receptors",
author = "Geijtenbeek, {Teunis B H} and {van Vliet}, {Sandra J} and Anneke Engering and {'t Hart}, {Bert A} and {van Kooyk}, Yvette",
year = "2004",
doi = "10.1146/annurev.immunol.22.012703.104558",
language = "English",
volume = "22",
pages = "33--54",
journal = "Annual Review of Immunology",
issn = "0732-0582",
publisher = "Annual Reviews Inc.",

}

Self- and nonself-recognition by C-type lectins on dendritic cells. / Geijtenbeek, Teunis B H; van Vliet, Sandra J; Engering, Anneke; 't Hart, Bert A; van Kooyk, Yvette.

In: Annual Review of Immunology, Vol. 22, 2004, p. 33-54.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Self- and nonself-recognition by C-type lectins on dendritic cells

AU - Geijtenbeek, Teunis B H

AU - van Vliet, Sandra J

AU - Engering, Anneke

AU - 't Hart, Bert A

AU - van Kooyk, Yvette

PY - 2004

Y1 - 2004

N2 - Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that collect antigen in body tissues and transport them to draining lymph nodes. Antigenic peptides are loaded onto major histocompatibility complex (MHC) molecules for presentation to naive T cells, resulting in the induction of cellular and humoral immune responses. DCs take up antigen through phagocytosis, pinocytosis, and endocytosis via different groups of receptor families, such as Fc receptors for antigen-antibody complexes, C-type lectin receptors (CLRs) for glycoproteins, and pattern recognition receptors, such as Toll-like receptors (TLRs), for microbial antigens. Uptake of antigen by CLRs leads to presentation of antigens on MHC class I and II molecules. DCs are well equipped to distinguish between self- and nonself-antigens by the variable expression of cell-surface receptors such as CLRs and TLRs. In the steady state, DCs are not immunologically quiescent but use their antigen-handling capacities to maintain peripheral tolerance. DCs are continuously sampling and presenting self- and harmless environmental proteins to silence immune activation. Uptake of self-components in the intestine and airways are good examples of sites where continuous presentation of self- and foreign antigens occurs without immune activation. In contrast, efficient antigen-specific immune activation occurs upon encounter of DCs with nonself-pathogens. Recognition of pathogens by DCs triggers specific receptors such as TLRs that result in DC maturation and subsequently immune activation. Here we discuss the concept that cross talk between TLRs and CLRs, differentially expressed by subsets of DCs, accounts for the different pathways to peripheral tolerance, such as deletion and suppression, and immune activation.

AB - Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that collect antigen in body tissues and transport them to draining lymph nodes. Antigenic peptides are loaded onto major histocompatibility complex (MHC) molecules for presentation to naive T cells, resulting in the induction of cellular and humoral immune responses. DCs take up antigen through phagocytosis, pinocytosis, and endocytosis via different groups of receptor families, such as Fc receptors for antigen-antibody complexes, C-type lectin receptors (CLRs) for glycoproteins, and pattern recognition receptors, such as Toll-like receptors (TLRs), for microbial antigens. Uptake of antigen by CLRs leads to presentation of antigens on MHC class I and II molecules. DCs are well equipped to distinguish between self- and nonself-antigens by the variable expression of cell-surface receptors such as CLRs and TLRs. In the steady state, DCs are not immunologically quiescent but use their antigen-handling capacities to maintain peripheral tolerance. DCs are continuously sampling and presenting self- and harmless environmental proteins to silence immune activation. Uptake of self-components in the intestine and airways are good examples of sites where continuous presentation of self- and foreign antigens occurs without immune activation. In contrast, efficient antigen-specific immune activation occurs upon encounter of DCs with nonself-pathogens. Recognition of pathogens by DCs triggers specific receptors such as TLRs that result in DC maturation and subsequently immune activation. Here we discuss the concept that cross talk between TLRs and CLRs, differentially expressed by subsets of DCs, accounts for the different pathways to peripheral tolerance, such as deletion and suppression, and immune activation.

KW - Animals

KW - Antigen Presentation/immunology

KW - Cell Communication/immunology

KW - Dendritic Cells/immunology

KW - Humans

KW - Lectins, C-Type/immunology

KW - Lymphocyte Activation/immunology

KW - Membrane Glycoproteins/immunology

KW - Receptors, Cell Surface/immunology

KW - Self Tolerance/immunology

KW - Signal Transduction/immunology

KW - Toll-Like Receptors

U2 - 10.1146/annurev.immunol.22.012703.104558

DO - 10.1146/annurev.immunol.22.012703.104558

M3 - Review article

VL - 22

SP - 33

EP - 54

JO - Annual Review of Immunology

JF - Annual Review of Immunology

SN - 0732-0582

ER -