Sensitieve en specifieke screening ter detectie van spina bifida door echografie in het tweede trimester; systematische review en meta-analyse

J. M. I. Vos, M. Offringa, C. M. Bilardo, J. G. Lijmer, P. G. Barth

Research output: Contribution to journalArticleProfessional


Objective. Evaluation of the diagnostic accuracy of ultrasound in the second trimester for the detection of spina bifida. Design. Systematic review and meta-analysis. Method. Medline and Embase were searched to identify prospective studies in a general pregnant population. Also, in the Cochrane Library, references of identified reports and recent reviews were checked for relevant studies. Retrieved abstracts were selected independently by 2 authors using predefined criteria. Assessment of quality and generalizability of the included studies and data extraction were performed by 3 authors independently. The data were tested for heterogeneity and pooled estimates of sensitivity and specificity were calculated for all studies. Results. 13 studies were included. Specificity was approximately 100% in all cases. Sensitivity varied from 40% to 100%. The summary point estimate for sensitivity was 71% with a 95% confidence interval of 59%-81%. Conclusion. Ultrasound in the second trimester is a specific investigation to detect spina bifida, which may detect seven out of ten defects. Used as a screening tool, it could contribute to a significant reduction in the number of children born with spina bifida.
Original languageDutch
Pages (from-to)1736-1741
JournalNederlands Tijdschrift voor Geneeskunde
Issue number36
Publication statusPublished - 2000
Externally publishedYes

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