Serum inflammatory proteins and cognitive decline in older persons

M. G. Dik*, C. Jonker, C. E. Hack, J. H. Smit, H. C. Comijs, P. Eikelenboom

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To assess whether serum levels of the inflammatory proteins α1-antichymotrypsin (ACT), C-reactive protein (CRP), interleukin-6 (IL-6), and albumin are associated with cognitive decline in older persons. Methods: The study sample consisted of 1,284 participants in the Longitudinal Aging Study Amsterdam, aged 62 to 85 years. Cognition was assessed on general cognition (Mini-Mental State Examination [MMSE]), memory (Auditory Verbal Learning Test), fluid intelligence (Raven's Colored Progressive Matrices), and information-processing speed (Coding Task) at baseline and at 3-year follow-up. Results: The highest tertile of ACT was associated with an increased risk of decline on the MMSE (age-, sex-, education-adjusted odds ratio [OR] 1.60; 95% CI: 1.05 to 2.43) but not on any other cognitive test score. CRP, IL-6, and albumin were not associated with cognitive decline on any cognitive test in our study. Conclusions: This population-based study showed that the serum inflammatory protein α1-antichymotrypsin is associated with cognitive decline in older persons, whereas C-reactive protein, interleukin-6, and albumin are not.

Original languageEnglish
Pages (from-to)1371-1377
Number of pages7
JournalNeurology
Volume64
Issue number8
DOIs
Publication statusPublished - 26 Apr 2005

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