Severe fatigue after treatment of ductal carcinoma in situ: A comparison with age-matched breast cancer survivors and healthy controls

H. J.G. Abrahams, L. Smits, M. de Lugt, W. K.de Roos, Y. Kamm, M. J. Heins, C. A.H.H.V.M. Verhagen, M. F.M. Gielissen, H. Knoop

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

© 2016 Elsevier Ltd Purpose Severe fatigue after treatment of ductal carcinoma in situ (DCIS) has not been studied before. The current study examined (i) the prevalence of severe fatigue in DCIS patients versus breast cancer survivors (BCS) and healthy controls (HC), (ii) quality of life and functioning of severely versus non-severely fatigued DCIS patients and BCS, and (iii) the association of fatigue with psychosocial and behavioral factors in DCIS patients. Methods 89 patients treated for DCIS were matched on age and gender to 67 BCS and 178 HC (ratio 1:1:2). Fatigue was measured with the Fatigue Severity subscale of the Checklist Individual Strength. Results 23% of DCIS patients, 25% of BCS, and 6% of HC were severely fatigued (DCIS versus HC: p <0.001). Severely fatigued DCIS patients had a lower quality of life and were more impaired in all domains of functioning than non-severely fatigued DCIS patients. Sleep problems, dysfunctional cognitions regarding fatigue, avoidance of activities, all-or-nothing behavior, perceived lack of social support, DCIS-related coping problems, and fear of future cancer occurrence were related to fatigue. Conclusions The prevalence of severe fatigue in DCIS patients was similar to BCS, but higher than in HC. Severely fatigued DCIS patients had a lower quality of life and more functional impairments. The psychosocial and behavioral fatigue-related factors in DCIS patients are known to perpetuate fatigue in BCS. These factors can be targeted in interventions for cancer-related fatigue. Our findings suggest that the same treatment elements might be applicable to severely fatigued DCIS patients.
Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalBreast
Volume31
DOIs
Publication statusPublished - 1 Feb 2017

Cite this

Abrahams, H. J.G. ; Smits, L. ; Lugt, M. de ; Roos, W. K.de ; Kamm, Y. ; Heins, M. J. ; Verhagen, C. A.H.H.V.M. ; Gielissen, M. F.M. ; Knoop, H. / Severe fatigue after treatment of ductal carcinoma in situ: A comparison with age-matched breast cancer survivors and healthy controls. In: Breast. 2017 ; Vol. 31. pp. 76-81.
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title = "Severe fatigue after treatment of ductal carcinoma in situ: A comparison with age-matched breast cancer survivors and healthy controls",
abstract = "{\circledC} 2016 Elsevier Ltd Purpose Severe fatigue after treatment of ductal carcinoma in situ (DCIS) has not been studied before. The current study examined (i) the prevalence of severe fatigue in DCIS patients versus breast cancer survivors (BCS) and healthy controls (HC), (ii) quality of life and functioning of severely versus non-severely fatigued DCIS patients and BCS, and (iii) the association of fatigue with psychosocial and behavioral factors in DCIS patients. Methods 89 patients treated for DCIS were matched on age and gender to 67 BCS and 178 HC (ratio 1:1:2). Fatigue was measured with the Fatigue Severity subscale of the Checklist Individual Strength. Results 23{\%} of DCIS patients, 25{\%} of BCS, and 6{\%} of HC were severely fatigued (DCIS versus HC: p <0.001). Severely fatigued DCIS patients had a lower quality of life and were more impaired in all domains of functioning than non-severely fatigued DCIS patients. Sleep problems, dysfunctional cognitions regarding fatigue, avoidance of activities, all-or-nothing behavior, perceived lack of social support, DCIS-related coping problems, and fear of future cancer occurrence were related to fatigue. Conclusions The prevalence of severe fatigue in DCIS patients was similar to BCS, but higher than in HC. Severely fatigued DCIS patients had a lower quality of life and more functional impairments. The psychosocial and behavioral fatigue-related factors in DCIS patients are known to perpetuate fatigue in BCS. These factors can be targeted in interventions for cancer-related fatigue. Our findings suggest that the same treatment elements might be applicable to severely fatigued DCIS patients.",
keywords = "Breast cancer, DCIS, Ductal carcinoma in situ, Fatigue, Quality of life",
author = "Abrahams, {H. J.G.} and L. Smits and Lugt, {M. de} and Roos, {W. K.de} and Y. Kamm and Heins, {M. J.} and Verhagen, {C. A.H.H.V.M.} and Gielissen, {M. F.M.} and H. Knoop",
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Severe fatigue after treatment of ductal carcinoma in situ: A comparison with age-matched breast cancer survivors and healthy controls. / Abrahams, H. J.G.; Smits, L.; Lugt, M. de; Roos, W. K.de; Kamm, Y.; Heins, M. J.; Verhagen, C. A.H.H.V.M.; Gielissen, M. F.M.; Knoop, H.

In: Breast, Vol. 31, 01.02.2017, p. 76-81.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Severe fatigue after treatment of ductal carcinoma in situ: A comparison with age-matched breast cancer survivors and healthy controls

AU - Abrahams, H. J.G.

AU - Smits, L.

AU - Lugt, M. de

AU - Roos, W. K.de

AU - Kamm, Y.

AU - Heins, M. J.

AU - Verhagen, C. A.H.H.V.M.

AU - Gielissen, M. F.M.

AU - Knoop, H.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - © 2016 Elsevier Ltd Purpose Severe fatigue after treatment of ductal carcinoma in situ (DCIS) has not been studied before. The current study examined (i) the prevalence of severe fatigue in DCIS patients versus breast cancer survivors (BCS) and healthy controls (HC), (ii) quality of life and functioning of severely versus non-severely fatigued DCIS patients and BCS, and (iii) the association of fatigue with psychosocial and behavioral factors in DCIS patients. Methods 89 patients treated for DCIS were matched on age and gender to 67 BCS and 178 HC (ratio 1:1:2). Fatigue was measured with the Fatigue Severity subscale of the Checklist Individual Strength. Results 23% of DCIS patients, 25% of BCS, and 6% of HC were severely fatigued (DCIS versus HC: p <0.001). Severely fatigued DCIS patients had a lower quality of life and were more impaired in all domains of functioning than non-severely fatigued DCIS patients. Sleep problems, dysfunctional cognitions regarding fatigue, avoidance of activities, all-or-nothing behavior, perceived lack of social support, DCIS-related coping problems, and fear of future cancer occurrence were related to fatigue. Conclusions The prevalence of severe fatigue in DCIS patients was similar to BCS, but higher than in HC. Severely fatigued DCIS patients had a lower quality of life and more functional impairments. The psychosocial and behavioral fatigue-related factors in DCIS patients are known to perpetuate fatigue in BCS. These factors can be targeted in interventions for cancer-related fatigue. Our findings suggest that the same treatment elements might be applicable to severely fatigued DCIS patients.

AB - © 2016 Elsevier Ltd Purpose Severe fatigue after treatment of ductal carcinoma in situ (DCIS) has not been studied before. The current study examined (i) the prevalence of severe fatigue in DCIS patients versus breast cancer survivors (BCS) and healthy controls (HC), (ii) quality of life and functioning of severely versus non-severely fatigued DCIS patients and BCS, and (iii) the association of fatigue with psychosocial and behavioral factors in DCIS patients. Methods 89 patients treated for DCIS were matched on age and gender to 67 BCS and 178 HC (ratio 1:1:2). Fatigue was measured with the Fatigue Severity subscale of the Checklist Individual Strength. Results 23% of DCIS patients, 25% of BCS, and 6% of HC were severely fatigued (DCIS versus HC: p <0.001). Severely fatigued DCIS patients had a lower quality of life and were more impaired in all domains of functioning than non-severely fatigued DCIS patients. Sleep problems, dysfunctional cognitions regarding fatigue, avoidance of activities, all-or-nothing behavior, perceived lack of social support, DCIS-related coping problems, and fear of future cancer occurrence were related to fatigue. Conclusions The prevalence of severe fatigue in DCIS patients was similar to BCS, but higher than in HC. Severely fatigued DCIS patients had a lower quality of life and more functional impairments. The psychosocial and behavioral fatigue-related factors in DCIS patients are known to perpetuate fatigue in BCS. These factors can be targeted in interventions for cancer-related fatigue. Our findings suggest that the same treatment elements might be applicable to severely fatigued DCIS patients.

KW - Breast cancer

KW - DCIS

KW - Ductal carcinoma in situ

KW - Fatigue

KW - Quality of life

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U2 - 10.1016/j.breast.2016.10.020

DO - 10.1016/j.breast.2016.10.020

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