Severe spontaneous hemoperitoneum in pregnancy may be linked to in vitro fertilization in patients with endometriosis: a systematic review

I A Brosens, M. C. Lier, V. Mijatovic, M. Habiba, G. Benagiano

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To evaluate existing evidence of a possible association in women with endometriosis between controlled ovarian hyper-stimulation plus embryo transfer (COH-ET) and the occurrence of spontaneous hemoperitoneum in pregnancy (SHiP). Design: Comprehensive review. Setting: Not applicable. Patient(s): None. Intervention(s): An electronic literature search up to February 2016 was conducted using Scopus and PubMed. Main Outcome Measure(s): The role of COH-ET in SHiP. Result(s): Controlled ovarian hyperstimulation plus embryo transfer may increase the severity or incidence of the rare condition known as SHiP. An analysis of published cases shows that bleeding often occurs from multiple or diffuse sites, mainly situated in the posterior pelvic cavity, making it difficult to control without interfering with the pregnancy itself. Spontaneous hemoperitoneum in pregnancy is linked to adverse perinatal outcomes, including stillbirth, neonatal mortality, and very low or low birth weight. In 14 cases a biopsy of the bleeding site was obtained, and in all cases, even in the absence of visible endometriosis, decidualization was documented. At present, the relatively small number of cases published prevents firm conclusions, although they are highly suggestive of a link between COH-ET in women with endometriosis and the occurrence and seriousness of SHiP. Conclusion(s): Spontaneous hemoperitoneum in pregnancy is a rare but potentially fatal complication for the pregnant woman and her unborn child. In vitro fertilization in women with severe endometriosis may be a risk factor for SHiP. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.
Original languageEnglish
Pages (from-to)692-703
Number of pages12
JournalFertility and Sterility
Volume106
DOIs
Publication statusPublished - 2016

Cite this

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title = "Severe spontaneous hemoperitoneum in pregnancy may be linked to in vitro fertilization in patients with endometriosis: a systematic review",
abstract = "Objective: To evaluate existing evidence of a possible association in women with endometriosis between controlled ovarian hyper-stimulation plus embryo transfer (COH-ET) and the occurrence of spontaneous hemoperitoneum in pregnancy (SHiP). Design: Comprehensive review. Setting: Not applicable. Patient(s): None. Intervention(s): An electronic literature search up to February 2016 was conducted using Scopus and PubMed. Main Outcome Measure(s): The role of COH-ET in SHiP. Result(s): Controlled ovarian hyperstimulation plus embryo transfer may increase the severity or incidence of the rare condition known as SHiP. An analysis of published cases shows that bleeding often occurs from multiple or diffuse sites, mainly situated in the posterior pelvic cavity, making it difficult to control without interfering with the pregnancy itself. Spontaneous hemoperitoneum in pregnancy is linked to adverse perinatal outcomes, including stillbirth, neonatal mortality, and very low or low birth weight. In 14 cases a biopsy of the bleeding site was obtained, and in all cases, even in the absence of visible endometriosis, decidualization was documented. At present, the relatively small number of cases published prevents firm conclusions, although they are highly suggestive of a link between COH-ET in women with endometriosis and the occurrence and seriousness of SHiP. Conclusion(s): Spontaneous hemoperitoneum in pregnancy is a rare but potentially fatal complication for the pregnant woman and her unborn child. In vitro fertilization in women with severe endometriosis may be a risk factor for SHiP. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.",
author = "Brosens, {I A} and Lier, {M. C.} and V. Mijatovic and M. Habiba and G. Benagiano",
note = "M1 - 3 ISI Document Delivery No.: EA4GT Times Cited: 2 Cited Reference Count: 81 Brosens, Ivo A. Lier, Marit C. Mijatovic, Velja Habiba, Marwan Benagiano, Giuseppe 2 ELSEVIER SCIENCE INC NEW YORK FERTIL STERIL",
year = "2016",
doi = "10.1016/j.fertnstert.2016.05.025",
language = "English",
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Severe spontaneous hemoperitoneum in pregnancy may be linked to in vitro fertilization in patients with endometriosis: a systematic review. / Brosens, I A; Lier, M. C.; Mijatovic, V.; Habiba, M.; Benagiano, G.

In: Fertility and Sterility, Vol. 106, 2016, p. 692-703.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Severe spontaneous hemoperitoneum in pregnancy may be linked to in vitro fertilization in patients with endometriosis: a systematic review

AU - Brosens, I A

AU - Lier, M. C.

AU - Mijatovic, V.

AU - Habiba, M.

AU - Benagiano, G.

N1 - M1 - 3 ISI Document Delivery No.: EA4GT Times Cited: 2 Cited Reference Count: 81 Brosens, Ivo A. Lier, Marit C. Mijatovic, Velja Habiba, Marwan Benagiano, Giuseppe 2 ELSEVIER SCIENCE INC NEW YORK FERTIL STERIL

PY - 2016

Y1 - 2016

N2 - Objective: To evaluate existing evidence of a possible association in women with endometriosis between controlled ovarian hyper-stimulation plus embryo transfer (COH-ET) and the occurrence of spontaneous hemoperitoneum in pregnancy (SHiP). Design: Comprehensive review. Setting: Not applicable. Patient(s): None. Intervention(s): An electronic literature search up to February 2016 was conducted using Scopus and PubMed. Main Outcome Measure(s): The role of COH-ET in SHiP. Result(s): Controlled ovarian hyperstimulation plus embryo transfer may increase the severity or incidence of the rare condition known as SHiP. An analysis of published cases shows that bleeding often occurs from multiple or diffuse sites, mainly situated in the posterior pelvic cavity, making it difficult to control without interfering with the pregnancy itself. Spontaneous hemoperitoneum in pregnancy is linked to adverse perinatal outcomes, including stillbirth, neonatal mortality, and very low or low birth weight. In 14 cases a biopsy of the bleeding site was obtained, and in all cases, even in the absence of visible endometriosis, decidualization was documented. At present, the relatively small number of cases published prevents firm conclusions, although they are highly suggestive of a link between COH-ET in women with endometriosis and the occurrence and seriousness of SHiP. Conclusion(s): Spontaneous hemoperitoneum in pregnancy is a rare but potentially fatal complication for the pregnant woman and her unborn child. In vitro fertilization in women with severe endometriosis may be a risk factor for SHiP. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.

AB - Objective: To evaluate existing evidence of a possible association in women with endometriosis between controlled ovarian hyper-stimulation plus embryo transfer (COH-ET) and the occurrence of spontaneous hemoperitoneum in pregnancy (SHiP). Design: Comprehensive review. Setting: Not applicable. Patient(s): None. Intervention(s): An electronic literature search up to February 2016 was conducted using Scopus and PubMed. Main Outcome Measure(s): The role of COH-ET in SHiP. Result(s): Controlled ovarian hyperstimulation plus embryo transfer may increase the severity or incidence of the rare condition known as SHiP. An analysis of published cases shows that bleeding often occurs from multiple or diffuse sites, mainly situated in the posterior pelvic cavity, making it difficult to control without interfering with the pregnancy itself. Spontaneous hemoperitoneum in pregnancy is linked to adverse perinatal outcomes, including stillbirth, neonatal mortality, and very low or low birth weight. In 14 cases a biopsy of the bleeding site was obtained, and in all cases, even in the absence of visible endometriosis, decidualization was documented. At present, the relatively small number of cases published prevents firm conclusions, although they are highly suggestive of a link between COH-ET in women with endometriosis and the occurrence and seriousness of SHiP. Conclusion(s): Spontaneous hemoperitoneum in pregnancy is a rare but potentially fatal complication for the pregnant woman and her unborn child. In vitro fertilization in women with severe endometriosis may be a risk factor for SHiP. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the American Society for Reproductive Medicine.

U2 - 10.1016/j.fertnstert.2016.05.025

DO - 10.1016/j.fertnstert.2016.05.025

M3 - Article

VL - 106

SP - 692

EP - 703

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

ER -