TY - JOUR
T1 - Severity of obesity and cardiometabolic risk factors in adults: Sex differences and role of physical activity. The HERMEX study
T2 - International Journal of Cardiology
AU - Soriano-Maldonado, A.
AU - Aparicio Garcia-Molina, Virginia
AU - Felix-Redondo, Francisco J.
AU - Fernandez-Berges, Daniel
N1 - ISI Document Delivery No.: EB0LV Times Cited: 0 Cited Reference Count: 55 Soriano-Maldonado, Alberto Aparicio, Virginia A. Felix-Redondo, Francisco J. Fernandez-Berges, Daniel Soriano-Maldonado, Alberto/0000-0002-4626-420X Plan Nacional de Investigacion Cientifica [PI071218]; Actions for research intensification [INT 07/289, 09/030]; Instituto de Salud Carlos III; Integral Plan for cardiovascular diseases in Extremadura, Fundesalud, Junta de Extremadura; Spanish Ministry of Education, Culture and Sport [FPU12/00963]; Andalucia Talent Hub Program; European Union [291780]; Ministry of Economy, Innovation, Science and Employment, Government of Andalucia; [EMER 07/046] This project was funded by the "Plan Nacional de Investigacion Cientifica" 2004-2007 (PI071218), by fundings for emerging research groups (EMER 07/046), by Actions for research intensification (INT 07/289, 09/030) by the "Instituto de Salud Carlos III", and a grant by the Integral Plan for cardiovascular diseases in Extremadura, Fundesalud, Junta de Extremadura. AS-M (grant number: FPU12/00963) was supported by the Spanish Ministry of Education, Culture and Sport. VAA was supported by the Andalucia Talent Hub Program launched by the Andalusian Knowledge Agency, co-funded by the European Union Seventh Framework Program, Marie Sklodowska-Curie actions (COFUND-Grant Agreement no. 291780) and the Ministry of Economy, Innovation, Science and Employment, Government of Andalucia. 0 7 ELSEVIER IRELAND LTD CLARE INT J CARDIOL
PY - 2016
Y1 - 2016
N2 - Background: The aims of this study were 1) to examine potential sex-related differences in major cardiometabolic risk factors among severe/morbid obese (body mass index [BMI] >= 35) individuals; 2) to assess whether severity of obesity is associated with more adverse cardiometabolic risk factors in women and men, and 3) to assess whether being physically active (>= 500 metabolic equivalents [MET-minutes per week]) may play a role in the association between severity of obesity and the cardiometabolic risk profile. Methods: A total of 886 (438men) obese individuals participated in a population-based cross-sectional study. We categorized participants as grade I (BMI 30-34.99) and grade II/III (BMI >= 35) obese. We measured markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]) blood pressure and renal function, as well as self-reported physical activity. Results: Triglycerides, insulin, HOMA-IR, systolic blood pressure and creatinine levels were higher in severe/morbid obese men than women (all, P <0.05), while women presented higher HDL cholesterol and hs-CRP (P <0.05) than men. Severe/morbid obesity was associated with higher triglycerides, hs-CRP, insulin and insulin resistance, diastolic blood pressure and higher odds of hypertension than grade I obesity both in women and men (all, P <0.05). Severe/morbid obese individuals who were physically inactive presented the least favorable cardiometabolic profile (P <0.05). Conclusions: Severe/morbid obesity is associated with more adverse cardiometabolic risk factors both in women and men. Severe/morbid obese men are more affected than women regarding their cardiometabolic profile, although women presented higher inflammation. Physically inactive individuals with severe/morbid obesity had the most adverse clustered cardiometabolic risk profile. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
AB - Background: The aims of this study were 1) to examine potential sex-related differences in major cardiometabolic risk factors among severe/morbid obese (body mass index [BMI] >= 35) individuals; 2) to assess whether severity of obesity is associated with more adverse cardiometabolic risk factors in women and men, and 3) to assess whether being physically active (>= 500 metabolic equivalents [MET-minutes per week]) may play a role in the association between severity of obesity and the cardiometabolic risk profile. Methods: A total of 886 (438men) obese individuals participated in a population-based cross-sectional study. We categorized participants as grade I (BMI 30-34.99) and grade II/III (BMI >= 35) obese. We measured markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]) blood pressure and renal function, as well as self-reported physical activity. Results: Triglycerides, insulin, HOMA-IR, systolic blood pressure and creatinine levels were higher in severe/morbid obese men than women (all, P <0.05), while women presented higher HDL cholesterol and hs-CRP (P <0.05) than men. Severe/morbid obesity was associated with higher triglycerides, hs-CRP, insulin and insulin resistance, diastolic blood pressure and higher odds of hypertension than grade I obesity both in women and men (all, P <0.05). Severe/morbid obese individuals who were physically inactive presented the least favorable cardiometabolic profile (P <0.05). Conclusions: Severe/morbid obesity is associated with more adverse cardiometabolic risk factors both in women and men. Severe/morbid obese men are more affected than women regarding their cardiometabolic profile, although women presented higher inflammation. Physically inactive individuals with severe/morbid obesity had the most adverse clustered cardiometabolic risk profile. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.ijcard.2016.07.253
DO - 10.1016/j.ijcard.2016.07.253
M3 - Article
C2 - 27543708
VL - 223
SP - 352
EP - 359
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -