Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extendedWMregions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation ofWMmicrostructure, although sex chromosomegenes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role.

Original languageEnglish
Pages (from-to)2994-3001
Number of pages8
JournalCerebral Cortex
Volume27
Issue number5
DOIs
Publication statusPublished - 1 May 2017

Cite this

@article{e3708e5d52504d32aa083df5dcf50ae0,
title = "Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure",
abstract = "Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extendedWMregions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation ofWMmicrostructure, although sex chromosomegenes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role.",
keywords = "Androgens, CAIS, DTI, Sexual differentiation, white matter",
author = "{Van Hemmen}, J. and Saris, {I. M.J.} and Cohen-Kettenis, {P. T.} and Veltman, {D. J.} and Pouwels, {P. J.W.} and J. Bakker",
year = "2017",
month = "5",
day = "1",
doi = "10.1093/cercor/bhw156",
language = "English",
volume = "27",
pages = "2994--3001",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
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}

Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure. / Van Hemmen, J.; Saris, I. M.J.; Cohen-Kettenis, P. T.; Veltman, D. J.; Pouwels, P. J.W.; Bakker, J.

In: Cerebral Cortex, Vol. 27, No. 5, 01.05.2017, p. 2994-3001.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure

AU - Van Hemmen, J.

AU - Saris, I. M.J.

AU - Cohen-Kettenis, P. T.

AU - Veltman, D. J.

AU - Pouwels, P. J.W.

AU - Bakker, J.

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AB - Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extendedWMregions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation ofWMmicrostructure, although sex chromosomegenes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role.

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