Sex hormones and cognitive decline in elderly men

Majon Muller; Annewieke W. van den Beld; Diederick E. Grobbee; Frank H. de Jong; Steven W.J. Lamberts

doi:10.1016/j.psyneuen.2008.08.008

Sex hormones and cognitive decline in elderly men

Majon Muller^*, Annewieke W. van den Beld, Diederick E. Grobbee, Frank H. de Jong, Steven W.J. Lamberts

^*Corresponding author for this work

Internal medicine

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Decline of cognitive function with age may be due, in part, to hormonal changes and it has been hypothesized that higher levels of endogenous sex hormones preserve brain function. The aim of this prospective cohort study was to determine the relative contribution of endogenous sex hormones to cognitive decline in a population-based sample of 242 elderly men aged 73-91 at baseline. Endogenous sex hormone levels were measured at baseline and participants underwent a cognitive assessment at baseline and at follow-up after 4 years. Higher estradiol (total and bioavailable) and estrone levels were associated with an increased risk of cognitive decline in elderly men independent of age, cardiovascular risk factors, atherosclerosis, and APOE genotype. These findings do not support the hypotheses that higher levels of endogenous sex hormones preserve brain function.

Original language	English
Pages (from-to)	27-31
Number of pages	5
Journal	Psychoneuroendocrinology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.psyneuen.2008.08.008
Publication status	Published - 1 Jan 2009

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10.1016/j.psyneuen.2008.08.008

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Sex hormones and cognitive decline in elderly men

Abstract

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