Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications

Federica Piani, Isabella Melena, Kalie L. Tommerdahl, Natalie Nokoff, Robert G. Nelson, Meda E. Pavkov, Daniël H. van Raalte, David Z. Cherney, Richard J. Johnson, Kristen J. Nadeau, Petter Bjornstad*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease (DKD) and explain differences observed in disease phenotypes, responses to interventions, and disease progression between men and women with diabetes. Therefore, omitting the consideration of sex as a biological factor may result in delayed diagnoses and suboptimal therapies. This review will summarize the effects of sexual dimorphism on putative metabolic and molecular mechanisms underlying DKD, and the potential implications of these differences on therapeutic interventions. To successfully implement precision medicine, we require a better understanding of sexual dimorphism in the pathophysiologic progression of DKD. Such insights can unveil sex-specific therapeutic targets that have the potential to maximize efficacy while minimizing adverse events.
Original languageEnglish
Article number107841
JournalJournal of Diabetes and its Complications
Volume35
Issue number4
Early online date2021
DOIs
Publication statusPublished - Apr 2021

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