TY - JOUR
T1 - Sex-related differences in diabetic kidney disease: A review on the mechanisms and potential therapeutic implications
AU - Piani, Federica
AU - Melena, Isabella
AU - Tommerdahl, Kalie L.
AU - Nokoff, Natalie
AU - Nelson, Robert G.
AU - Pavkov, Meda E.
AU - van Raalte, Daniël H.
AU - Cherney, David Z.
AU - Johnson, Richard J.
AU - Nadeau, Kristen J.
AU - Bjornstad, Petter
N1 - Funding Information:
Financial support for this work provided by the JDRF grant numbers 2-SRA-2018-627-M-B and 2-SRA-2019-845-S-B (P.B.), and NIH/NIDDK grant numbers K23-DK116720 (P.B.), K24-HL145076 (K.J.N.), UL1-RR025780 (University of Colorado Denver), support from Center for Women's Health Research at University of Colorado, the Department of Pediatrics, Section of Endocrinology and Barbara Davis Center for Diabetes at University of Colorado School of Medicine, and by the Intramural Research Program of the NIDDK.
Publisher Copyright:
© 2020 Elsevier Inc.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease (DKD) and explain differences observed in disease phenotypes, responses to interventions, and disease progression between men and women with diabetes. Therefore, omitting the consideration of sex as a biological factor may result in delayed diagnoses and suboptimal therapies. This review will summarize the effects of sexual dimorphism on putative metabolic and molecular mechanisms underlying DKD, and the potential implications of these differences on therapeutic interventions. To successfully implement precision medicine, we require a better understanding of sexual dimorphism in the pathophysiologic progression of DKD. Such insights can unveil sex-specific therapeutic targets that have the potential to maximize efficacy while minimizing adverse events.
AB - Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease (DKD) and explain differences observed in disease phenotypes, responses to interventions, and disease progression between men and women with diabetes. Therefore, omitting the consideration of sex as a biological factor may result in delayed diagnoses and suboptimal therapies. This review will summarize the effects of sexual dimorphism on putative metabolic and molecular mechanisms underlying DKD, and the potential implications of these differences on therapeutic interventions. To successfully implement precision medicine, we require a better understanding of sexual dimorphism in the pathophysiologic progression of DKD. Such insights can unveil sex-specific therapeutic targets that have the potential to maximize efficacy while minimizing adverse events.
KW - Diabetic kidney disease
KW - Diabetic nephropathy
KW - Sex-related differences
KW - Sexual dimorphism
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099573831&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33423908
UR - http://www.scopus.com/inward/record.url?scp=85099573831&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2020.107841
DO - 10.1016/j.jdiacomp.2020.107841
M3 - Review article
C2 - 33423908
VL - 35
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 4
M1 - 107841
ER -