Sex-specific aspects of left and right ventricular volume regulation in patients following tetralogy of Fallot repair

Peter L.M. Kerkhof, B. W. Yoo, Peter M. Van De Ven, Neal Handly

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Ejection fraction (EF) is applied as a clinically relevant metric to assess both left (LV) and right ventricular (RV) function. EF depends on the interplay between end-systolic volume (ESV) and end-diastolic volume (EDV). The role of the two constitutive components is of particular interest for the follow-up study of Fallot patients at risk for RV volume overload. The volume regulation graph (VRG) relates ESV to EDV and has been advanced as a central tool to describe LV and RV function. The method permits additional analysis of the impact of clinically relevant determinants such as sex and age. Following Fallot repair and using MRI we evaluated LV and RV volumes in 124 patients (50 females), who were not taking any medication. Volumes were indexed for body surface area (BSA). The VRG regression lines are similar for both sexes, also when stratified for age (i.e. younger or older than 18 years), and different for LV and RV. However, RV ESV is larger (P=0.039) for adult males, as is RV EDV (P=0.026) in boys, relative to their female counterparts. For LV ESV we also found larger volumes, but only in boys (P=0.023) compared to girls. Average EF (only for RV) is lower in adult men compared to women (P=0.012), and to boys (P=0.007). These findings are partly in contrast with common observations made in individuals without a history of cardiac disease, where (with BSA indexation) LV and RV volumes are similar in children, but consistently larger in adult males. These results highlight the age- and sex-specific volumetric aspects of remodeling following surgery in Fallot patients, and emphasize the pivotal role of ESV size in both RV and LV.

Original languageEnglish
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1303-1306
Number of pages4
ISBN (Electronic)9781509028092
DOIs
Publication statusPublished - 13 Sep 2017
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: 11 Jul 201715 Jul 2017

Conference

Conference39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period11/07/201715/07/2017

Cite this

Kerkhof, P. L. M., Yoo, B. W., Van De Ven, P. M., & Handly, N. (2017). Sex-specific aspects of left and right ventricular volume regulation in patients following tetralogy of Fallot repair. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 1303-1306). [8037071] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8037071
Kerkhof, Peter L.M. ; Yoo, B. W. ; Van De Ven, Peter M. ; Handly, Neal. / Sex-specific aspects of left and right ventricular volume regulation in patients following tetralogy of Fallot repair. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 1303-1306
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abstract = "Ejection fraction (EF) is applied as a clinically relevant metric to assess both left (LV) and right ventricular (RV) function. EF depends on the interplay between end-systolic volume (ESV) and end-diastolic volume (EDV). The role of the two constitutive components is of particular interest for the follow-up study of Fallot patients at risk for RV volume overload. The volume regulation graph (VRG) relates ESV to EDV and has been advanced as a central tool to describe LV and RV function. The method permits additional analysis of the impact of clinically relevant determinants such as sex and age. Following Fallot repair and using MRI we evaluated LV and RV volumes in 124 patients (50 females), who were not taking any medication. Volumes were indexed for body surface area (BSA). The VRG regression lines are similar for both sexes, also when stratified for age (i.e. younger or older than 18 years), and different for LV and RV. However, RV ESV is larger (P=0.039) for adult males, as is RV EDV (P=0.026) in boys, relative to their female counterparts. For LV ESV we also found larger volumes, but only in boys (P=0.023) compared to girls. Average EF (only for RV) is lower in adult men compared to women (P=0.012), and to boys (P=0.007). These findings are partly in contrast with common observations made in individuals without a history of cardiac disease, where (with BSA indexation) LV and RV volumes are similar in children, but consistently larger in adult males. These results highlight the age- and sex-specific volumetric aspects of remodeling following surgery in Fallot patients, and emphasize the pivotal role of ESV size in both RV and LV.",
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Kerkhof, PLM, Yoo, BW, Van De Ven, PM & Handly, N 2017, Sex-specific aspects of left and right ventricular volume regulation in patients following tetralogy of Fallot repair. in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8037071, Institute of Electrical and Electronics Engineers Inc., pp. 1303-1306, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 11/07/2017. https://doi.org/10.1109/EMBC.2017.8037071

Sex-specific aspects of left and right ventricular volume regulation in patients following tetralogy of Fallot repair. / Kerkhof, Peter L.M.; Yoo, B. W.; Van De Ven, Peter M.; Handly, Neal.

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 1303-1306 8037071.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AB - Ejection fraction (EF) is applied as a clinically relevant metric to assess both left (LV) and right ventricular (RV) function. EF depends on the interplay between end-systolic volume (ESV) and end-diastolic volume (EDV). The role of the two constitutive components is of particular interest for the follow-up study of Fallot patients at risk for RV volume overload. The volume regulation graph (VRG) relates ESV to EDV and has been advanced as a central tool to describe LV and RV function. The method permits additional analysis of the impact of clinically relevant determinants such as sex and age. Following Fallot repair and using MRI we evaluated LV and RV volumes in 124 patients (50 females), who were not taking any medication. Volumes were indexed for body surface area (BSA). The VRG regression lines are similar for both sexes, also when stratified for age (i.e. younger or older than 18 years), and different for LV and RV. However, RV ESV is larger (P=0.039) for adult males, as is RV EDV (P=0.026) in boys, relative to their female counterparts. For LV ESV we also found larger volumes, but only in boys (P=0.023) compared to girls. Average EF (only for RV) is lower in adult men compared to women (P=0.012), and to boys (P=0.007). These findings are partly in contrast with common observations made in individuals without a history of cardiac disease, where (with BSA indexation) LV and RV volumes are similar in children, but consistently larger in adult males. These results highlight the age- and sex-specific volumetric aspects of remodeling following surgery in Fallot patients, and emphasize the pivotal role of ESV size in both RV and LV.

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Kerkhof PLM, Yoo BW, Van De Ven PM, Handly N. Sex-specific aspects of left and right ventricular volume regulation in patients following tetralogy of Fallot repair. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 1303-1306. 8037071 https://doi.org/10.1109/EMBC.2017.8037071