Short communication: High prevalence of transmitted antiretroviral drug resistance among newly HIV Type 1 diagnosed adults in mombasa, Kenya

Kim C.E. Sigaloff*, Kishor Mandaliya, Raph L. Hamers, Francis Otieno, Irene M. Jao, Frederick Lyagoba, Brian Magambo, Anne Kapaata, Nicaise Ndembi, Tobias F. Rinke De Wit

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In view of the recent antiretroviral therapy (ART) scale-up in Kenya, surveillance of transmitted HIV drug resistance (TDR) is important. A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive adults in Mombasa, Kenya. Surveillance drug resistance mutations (SDRMs) were identified according to the 2009 WHO list. HIV-1 subtypes were determined using REGA and SCUEAL subtyping tools. Genotypic test results were obtained for 68 of 81 participants, and SDRMs were identified in 9 samples. Resistance to nonnucleoside reverse transcriptase inhibitors (K103N) occurred in five participants, yielding a TDR prevalence of 7.4% (95% confidence interval 2.4-16.3%). Frequencies of HIV-1 subtypes were A (70.6%), C (5.9%), D (2.9%), and unique recombinant forms (20.6%). The TDR prevalence found in this survey is higher than previously reported in different regions in Kenya. These findings justify increased vigilance with respect to TDR surveillance in African regions where ART programs are scaled-up in order to inform treatment guidelines.

Original languageEnglish
Pages (from-to)833-837
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume28
Issue number9
DOIs
Publication statusPublished - 1 Sep 2012

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