Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation

Alexander S G O'Neill, Timo K van den Berg, Gregory E D Mullen

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Sialoadhesin (Sn, also known as Siglec-1 and CD169) is a macrophage-restricted cell surface receptor that is conserved across mammals. Sn is a member of the sialic acid-binding IgG-like lectin (Siglec) family of proteins characterized by affinity to specifically sialylated ligands, and under normal conditions is expressed on subsets of macrophages in secondary lymphoid tissues, such as lymph node and spleen. However, Sn-positive macrophages can also be found in a variety of pathological conditions, including (autoimmune) inflammatory infiltrates and tumours. Sn has been shown to contribute to sialylated pathogen uptake, antigen presentation and lymphocyte proliferation, and to influence both immunity and tolerance. This review presents Sn as a macrophage-specific marker of inflammation and immunoregulation with the potential to becoming an important biomarker for immunologically active macrophages and a target for therapy.

Original languageEnglish
Pages (from-to)198-207
Number of pages10
JournalImmunology
Volume138
Issue number3
DOIs
Publication statusPublished - Mar 2013

Cite this

O'Neill, Alexander S G ; van den Berg, Timo K ; Mullen, Gregory E D. / Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation. In: Immunology. 2013 ; Vol. 138, No. 3. pp. 198-207.
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title = "Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation",
abstract = "Sialoadhesin (Sn, also known as Siglec-1 and CD169) is a macrophage-restricted cell surface receptor that is conserved across mammals. Sn is a member of the sialic acid-binding IgG-like lectin (Siglec) family of proteins characterized by affinity to specifically sialylated ligands, and under normal conditions is expressed on subsets of macrophages in secondary lymphoid tissues, such as lymph node and spleen. However, Sn-positive macrophages can also be found in a variety of pathological conditions, including (autoimmune) inflammatory infiltrates and tumours. Sn has been shown to contribute to sialylated pathogen uptake, antigen presentation and lymphocyte proliferation, and to influence both immunity and tolerance. This review presents Sn as a macrophage-specific marker of inflammation and immunoregulation with the potential to becoming an important biomarker for immunologically active macrophages and a target for therapy.",
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Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation. / O'Neill, Alexander S G; van den Berg, Timo K; Mullen, Gregory E D.

In: Immunology, Vol. 138, No. 3, 03.2013, p. 198-207.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation

AU - O'Neill, Alexander S G

AU - van den Berg, Timo K

AU - Mullen, Gregory E D

N1 - © 2012 Blackwell Publishing Ltd.

PY - 2013/3

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N2 - Sialoadhesin (Sn, also known as Siglec-1 and CD169) is a macrophage-restricted cell surface receptor that is conserved across mammals. Sn is a member of the sialic acid-binding IgG-like lectin (Siglec) family of proteins characterized by affinity to specifically sialylated ligands, and under normal conditions is expressed on subsets of macrophages in secondary lymphoid tissues, such as lymph node and spleen. However, Sn-positive macrophages can also be found in a variety of pathological conditions, including (autoimmune) inflammatory infiltrates and tumours. Sn has been shown to contribute to sialylated pathogen uptake, antigen presentation and lymphocyte proliferation, and to influence both immunity and tolerance. This review presents Sn as a macrophage-specific marker of inflammation and immunoregulation with the potential to becoming an important biomarker for immunologically active macrophages and a target for therapy.

AB - Sialoadhesin (Sn, also known as Siglec-1 and CD169) is a macrophage-restricted cell surface receptor that is conserved across mammals. Sn is a member of the sialic acid-binding IgG-like lectin (Siglec) family of proteins characterized by affinity to specifically sialylated ligands, and under normal conditions is expressed on subsets of macrophages in secondary lymphoid tissues, such as lymph node and spleen. However, Sn-positive macrophages can also be found in a variety of pathological conditions, including (autoimmune) inflammatory infiltrates and tumours. Sn has been shown to contribute to sialylated pathogen uptake, antigen presentation and lymphocyte proliferation, and to influence both immunity and tolerance. This review presents Sn as a macrophage-specific marker of inflammation and immunoregulation with the potential to becoming an important biomarker for immunologically active macrophages and a target for therapy.

KW - Animals

KW - Autoimmune Diseases/immunology

KW - Biomarkers/metabolism

KW - Gene Expression Regulation

KW - Humans

KW - Inflammation/genetics

KW - Macrophages/immunology

KW - N-Acetylneuraminic Acid/metabolism

KW - Neoplasms/immunology

KW - Sialic Acid Binding Ig-like Lectin 1/genetics

U2 - 10.1111/imm.12042

DO - 10.1111/imm.12042

M3 - Review article

VL - 138

SP - 198

EP - 207

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - 3

ER -