Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

Mark W. Logue, Sanne J.H. van Rooij, Emily L. Dennis, Sarah L. Davis, Jasmeet P. Hayes, Jennifer S. Stevens, Maria Densmore, Courtney C. Haswell, Jonathan Ipser, Saskia B.J. Koch, Mayuresh Korgaonkar, Lauren A.M. Lebois, Matthew Peverill, Justin T. Baker, Premika S.W. Boedhoe, Jessie L. Frijling, Staci A. Gruber, Ilan Harpaz-Rotem, Neda Jahanshad, Sheri Koopowitz & 34 others Ifat Levy, Laura Nawijn, Lauren O'Connor, Miranda Olff, David H. Salat, Margaret A. Sheridan, Jeffrey M. Spielberg, Mirjam van Zuiden, Sherry R. Winternitz, Jonathan D. Wolff, Erika J. Wolf, Xin Wang, Kristen Wrocklage, Chadi G. Abdallah, Richard A. Bryant, Elbert Geuze, Tanja Jovanovic, Milissa L. Kaufman, Anthony P. King, John H. Krystal, Jim Lagopoulos, Maxwell Bennett, Ruth Lanius, Israel Liberzon, Regina E. McGlinchey, Katie A. McLaughlin, William P. Milberg, Mark W. Miller, Kerry J. Ressler, Dick J. Veltman, Dan J. Stein, Kathleen Thomaes, Paul M. Thompson, Rajendra A. Morey

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

Original languageEnglish
Pages (from-to)244-253
Number of pages10
JournalBiological Psychiatry
Volume83
Issue number3
DOIs
Publication statusPublished - 1 Feb 2018

Cite this

Logue, Mark W. ; van Rooij, Sanne J.H. ; Dennis, Emily L. ; Davis, Sarah L. ; Hayes, Jasmeet P. ; Stevens, Jennifer S. ; Densmore, Maria ; Haswell, Courtney C. ; Ipser, Jonathan ; Koch, Saskia B.J. ; Korgaonkar, Mayuresh ; Lebois, Lauren A.M. ; Peverill, Matthew ; Baker, Justin T. ; Boedhoe, Premika S.W. ; Frijling, Jessie L. ; Gruber, Staci A. ; Harpaz-Rotem, Ilan ; Jahanshad, Neda ; Koopowitz, Sheri ; Levy, Ifat ; Nawijn, Laura ; O'Connor, Lauren ; Olff, Miranda ; Salat, David H. ; Sheridan, Margaret A. ; Spielberg, Jeffrey M. ; van Zuiden, Mirjam ; Winternitz, Sherry R. ; Wolff, Jonathan D. ; Wolf, Erika J. ; Wang, Xin ; Wrocklage, Kristen ; Abdallah, Chadi G. ; Bryant, Richard A. ; Geuze, Elbert ; Jovanovic, Tanja ; Kaufman, Milissa L. ; King, Anthony P. ; Krystal, John H. ; Lagopoulos, Jim ; Bennett, Maxwell ; Lanius, Ruth ; Liberzon, Israel ; McGlinchey, Regina E. ; McLaughlin, Katie A. ; Milberg, William P. ; Miller, Mark W. ; Ressler, Kerry J. ; Veltman, Dick J. ; Stein, Dan J. ; Thomaes, Kathleen ; Thompson, Paul M. ; Morey, Rajendra A. / Smaller Hippocampal Volume in Posttraumatic Stress Disorder : A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. In: Biological Psychiatry. 2018 ; Vol. 83, No. 3. pp. 244-253.
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title = "Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia",
abstract = "Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.",
keywords = "Amygdala, Childhood trauma, Gender differences, Hippocampus, PTSD, Structural MRI",
author = "Logue, {Mark W.} and {van Rooij}, {Sanne J.H.} and Dennis, {Emily L.} and Davis, {Sarah L.} and Hayes, {Jasmeet P.} and Stevens, {Jennifer S.} and Maria Densmore and Haswell, {Courtney C.} and Jonathan Ipser and Koch, {Saskia B.J.} and Mayuresh Korgaonkar and Lebois, {Lauren A.M.} and Matthew Peverill and Baker, {Justin T.} and Boedhoe, {Premika S.W.} and Frijling, {Jessie L.} and Gruber, {Staci A.} and Ilan Harpaz-Rotem and Neda Jahanshad and Sheri Koopowitz and Ifat Levy and Laura Nawijn and Lauren O'Connor and Miranda Olff and Salat, {David H.} and Sheridan, {Margaret A.} and Spielberg, {Jeffrey M.} and {van Zuiden}, Mirjam and Winternitz, {Sherry R.} and Wolff, {Jonathan D.} and Wolf, {Erika J.} and Xin Wang and Kristen Wrocklage and Abdallah, {Chadi G.} and Bryant, {Richard A.} and Elbert Geuze and Tanja Jovanovic and Kaufman, {Milissa L.} and King, {Anthony P.} and Krystal, {John H.} and Jim Lagopoulos and Maxwell Bennett and Ruth Lanius and Israel Liberzon and McGlinchey, {Regina E.} and McLaughlin, {Katie A.} and Milberg, {William P.} and Miller, {Mark W.} and Ressler, {Kerry J.} and Veltman, {Dick J.} and Stein, {Dan J.} and Kathleen Thomaes and Thompson, {Paul M.} and Morey, {Rajendra A.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.biopsych.2017.09.006",
language = "English",
volume = "83",
pages = "244--253",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
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Logue, MW, van Rooij, SJH, Dennis, EL, Davis, SL, Hayes, JP, Stevens, JS, Densmore, M, Haswell, CC, Ipser, J, Koch, SBJ, Korgaonkar, M, Lebois, LAM, Peverill, M, Baker, JT, Boedhoe, PSW, Frijling, JL, Gruber, SA, Harpaz-Rotem, I, Jahanshad, N, Koopowitz, S, Levy, I, Nawijn, L, O'Connor, L, Olff, M, Salat, DH, Sheridan, MA, Spielberg, JM, van Zuiden, M, Winternitz, SR, Wolff, JD, Wolf, EJ, Wang, X, Wrocklage, K, Abdallah, CG, Bryant, RA, Geuze, E, Jovanovic, T, Kaufman, ML, King, AP, Krystal, JH, Lagopoulos, J, Bennett, M, Lanius, R, Liberzon, I, McGlinchey, RE, McLaughlin, KA, Milberg, WP, Miller, MW, Ressler, KJ, Veltman, DJ, Stein, DJ, Thomaes, K, Thompson, PM & Morey, RA 2018, 'Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia' Biological Psychiatry, vol. 83, no. 3, pp. 244-253. https://doi.org/10.1016/j.biopsych.2017.09.006

Smaller Hippocampal Volume in Posttraumatic Stress Disorder : A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. / Logue, Mark W.; van Rooij, Sanne J.H.; Dennis, Emily L.; Davis, Sarah L.; Hayes, Jasmeet P.; Stevens, Jennifer S.; Densmore, Maria; Haswell, Courtney C.; Ipser, Jonathan; Koch, Saskia B.J.; Korgaonkar, Mayuresh; Lebois, Lauren A.M.; Peverill, Matthew; Baker, Justin T.; Boedhoe, Premika S.W.; Frijling, Jessie L.; Gruber, Staci A.; Harpaz-Rotem, Ilan; Jahanshad, Neda; Koopowitz, Sheri; Levy, Ifat; Nawijn, Laura; O'Connor, Lauren; Olff, Miranda; Salat, David H.; Sheridan, Margaret A.; Spielberg, Jeffrey M.; van Zuiden, Mirjam; Winternitz, Sherry R.; Wolff, Jonathan D.; Wolf, Erika J.; Wang, Xin; Wrocklage, Kristen; Abdallah, Chadi G.; Bryant, Richard A.; Geuze, Elbert; Jovanovic, Tanja; Kaufman, Milissa L.; King, Anthony P.; Krystal, John H.; Lagopoulos, Jim; Bennett, Maxwell; Lanius, Ruth; Liberzon, Israel; McGlinchey, Regina E.; McLaughlin, Katie A.; Milberg, William P.; Miller, Mark W.; Ressler, Kerry J.; Veltman, Dick J.; Stein, Dan J.; Thomaes, Kathleen; Thompson, Paul M.; Morey, Rajendra A.

In: Biological Psychiatry, Vol. 83, No. 3, 01.02.2018, p. 244-253.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Smaller Hippocampal Volume in Posttraumatic Stress Disorder

T2 - A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia

AU - Logue, Mark W.

AU - van Rooij, Sanne J.H.

AU - Dennis, Emily L.

AU - Davis, Sarah L.

AU - Hayes, Jasmeet P.

AU - Stevens, Jennifer S.

AU - Densmore, Maria

AU - Haswell, Courtney C.

AU - Ipser, Jonathan

AU - Koch, Saskia B.J.

AU - Korgaonkar, Mayuresh

AU - Lebois, Lauren A.M.

AU - Peverill, Matthew

AU - Baker, Justin T.

AU - Boedhoe, Premika S.W.

AU - Frijling, Jessie L.

AU - Gruber, Staci A.

AU - Harpaz-Rotem, Ilan

AU - Jahanshad, Neda

AU - Koopowitz, Sheri

AU - Levy, Ifat

AU - Nawijn, Laura

AU - O'Connor, Lauren

AU - Olff, Miranda

AU - Salat, David H.

AU - Sheridan, Margaret A.

AU - Spielberg, Jeffrey M.

AU - van Zuiden, Mirjam

AU - Winternitz, Sherry R.

AU - Wolff, Jonathan D.

AU - Wolf, Erika J.

AU - Wang, Xin

AU - Wrocklage, Kristen

AU - Abdallah, Chadi G.

AU - Bryant, Richard A.

AU - Geuze, Elbert

AU - Jovanovic, Tanja

AU - Kaufman, Milissa L.

AU - King, Anthony P.

AU - Krystal, John H.

AU - Lagopoulos, Jim

AU - Bennett, Maxwell

AU - Lanius, Ruth

AU - Liberzon, Israel

AU - McGlinchey, Regina E.

AU - McLaughlin, Katie A.

AU - Milberg, William P.

AU - Miller, Mark W.

AU - Ressler, Kerry J.

AU - Veltman, Dick J.

AU - Stein, Dan J.

AU - Thomaes, Kathleen

AU - Thompson, Paul M.

AU - Morey, Rajendra A.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

AB - Background Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. Methods We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. Results In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = −0.17, p =.00054), and smaller amygdalae (d = −0.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). Conclusions Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma.

KW - Amygdala

KW - Childhood trauma

KW - Gender differences

KW - Hippocampus

KW - PTSD

KW - Structural MRI

UR - http://www.scopus.com/inward/record.url?scp=85034845116&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2017.09.006

DO - 10.1016/j.biopsych.2017.09.006

M3 - Article

VL - 83

SP - 244

EP - 253

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 3

ER -