Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients

M Lijffijt, P S Van Dam, J L Kenemans, H P F Koppeschaar, W R de Vries, M L Drent, A Wittenberg, C Kemner

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Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning.

Original languageEnglish
Pages (from-to)123-6
Number of pages4
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 19 Dec 2003

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