Spatiotemporal network alterations in experimental focal cortical epilepsy: MRI-based longitudinal functional connectivity and weighted graph analysis

W. M. Otte, R. M. Dijkhuizen, C. J. Stam, K. Van Der Marel, M. P.A. Van Meer, M. A. Viergever, K. P.J. Braun

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

There is increasing evidence that the topology of brain networks may be changed in epilepsy. In particular, a random topology has been suggested as an explanation for lower seizure thresholds. To test this hypothesis, we assessed focal epileptic and healthy networks over time using resting state functional MRI and weighted graph theoretical analysis in a rat model. Brain networks in focal epilepsy were globally affected, toward a more ordered network topology. Networks largely normalized at ten weeks after epilepsy induction. Graph analysis provides a promising method to explore dynamical network alterations in epilepsy.

Original languageEnglish
Title of host publication2010 7th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2010 - Proceedings
Pages888-891
Number of pages4
DOIs
Publication statusPublished - 9 Aug 2010
Event7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Rotterdam, Netherlands
Duration: 14 Apr 201017 Apr 2010

Publication series

Name2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings

Conference

Conference7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010
CountryNetherlands
CityRotterdam
Period14/04/201017/04/2010

Cite this

Otte, W. M., Dijkhuizen, R. M., Stam, C. J., Van Der Marel, K., Van Meer, M. P. A., Viergever, M. A., & Braun, K. P. J. (2010). Spatiotemporal network alterations in experimental focal cortical epilepsy: MRI-based longitudinal functional connectivity and weighted graph analysis. In 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings (pp. 888-891). [5490129] (2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings). https://doi.org/10.1109/ISBI.2010.5490129