Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

Helena M Bijen, Chopie Hassan, Michel G D Kester, George M C Janssen, Pleun Hombrink, Arnoud H de Ru, Jan Wouter Drijfhout, Hugo D Meiring, Ad P de Jong, J H Frederik Falkenburg, Connie R Jimenez, Mirjam H M Heemskerk, Peter A van Veelen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on induction of graft versus leukemia by donor lymphocytes. Both graft versus leukemia and graft versus host disease are induced by T cells reactive against polymorphic peptides, called minor histocompatibility antigens (MiHA), which differ between patient and donor and are presented in the context of self-HLA (where HLA is human leukocyte antigen). The allelic counterpart (AC) of the MiHA is generally considered to be absent at the cell surface, based on the absence of immune responses directed against the AC. To study this in detail, we evaluate the recognition, HLA-binding affinity, and cell surface expression of three selected MiHA. By quantitative MS, we demonstrate the similarly abundant expression of both MiHA and AC at the cell surface. We conclude that the absent recognition of the AC cannot generally be explained by insufficient processing and presentation at the cell surface of the AC.

Original languageEnglish
Article number1700250
JournalProteomics
Volume18
Issue number12
Early online date18 Dec 2017
DOIs
Publication statusPublished - 1 Jun 2018

Cite this

Bijen, H. M., Hassan, C., Kester, M. G. D., Janssen, G. M. C., Hombrink, P., de Ru, A. H., ... van Veelen, P. A. (2018). Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface. Proteomics, 18(12), [1700250]. https://doi.org/10.1002/pmic.201700250
Bijen, Helena M ; Hassan, Chopie ; Kester, Michel G D ; Janssen, George M C ; Hombrink, Pleun ; de Ru, Arnoud H ; Drijfhout, Jan Wouter ; Meiring, Hugo D ; de Jong, Ad P ; Falkenburg, J H Frederik ; Jimenez, Connie R ; Heemskerk, Mirjam H M ; van Veelen, Peter A. / Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface. In: Proteomics. 2018 ; Vol. 18, No. 12.
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abstract = "Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on induction of graft versus leukemia by donor lymphocytes. Both graft versus leukemia and graft versus host disease are induced by T cells reactive against polymorphic peptides, called minor histocompatibility antigens (MiHA), which differ between patient and donor and are presented in the context of self-HLA (where HLA is human leukocyte antigen). The allelic counterpart (AC) of the MiHA is generally considered to be absent at the cell surface, based on the absence of immune responses directed against the AC. To study this in detail, we evaluate the recognition, HLA-binding affinity, and cell surface expression of three selected MiHA. By quantitative MS, we demonstrate the similarly abundant expression of both MiHA and AC at the cell surface. We conclude that the absent recognition of the AC cannot generally be explained by insufficient processing and presentation at the cell surface of the AC.",
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Bijen, HM, Hassan, C, Kester, MGD, Janssen, GMC, Hombrink, P, de Ru, AH, Drijfhout, JW, Meiring, HD, de Jong, AP, Falkenburg, JHF, Jimenez, CR, Heemskerk, MHM & van Veelen, PA 2018, 'Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface' Proteomics, vol. 18, no. 12, 1700250. https://doi.org/10.1002/pmic.201700250

Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface. / Bijen, Helena M; Hassan, Chopie; Kester, Michel G D; Janssen, George M C; Hombrink, Pleun; de Ru, Arnoud H; Drijfhout, Jan Wouter; Meiring, Hugo D; de Jong, Ad P; Falkenburg, J H Frederik; Jimenez, Connie R; Heemskerk, Mirjam H M; van Veelen, Peter A.

In: Proteomics, Vol. 18, No. 12, 1700250, 01.06.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

AU - Bijen, Helena M

AU - Hassan, Chopie

AU - Kester, Michel G D

AU - Janssen, George M C

AU - Hombrink, Pleun

AU - de Ru, Arnoud H

AU - Drijfhout, Jan Wouter

AU - Meiring, Hugo D

AU - de Jong, Ad P

AU - Falkenburg, J H Frederik

AU - Jimenez, Connie R

AU - Heemskerk, Mirjam H M

AU - van Veelen, Peter A

N1 - © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on induction of graft versus leukemia by donor lymphocytes. Both graft versus leukemia and graft versus host disease are induced by T cells reactive against polymorphic peptides, called minor histocompatibility antigens (MiHA), which differ between patient and donor and are presented in the context of self-HLA (where HLA is human leukocyte antigen). The allelic counterpart (AC) of the MiHA is generally considered to be absent at the cell surface, based on the absence of immune responses directed against the AC. To study this in detail, we evaluate the recognition, HLA-binding affinity, and cell surface expression of three selected MiHA. By quantitative MS, we demonstrate the similarly abundant expression of both MiHA and AC at the cell surface. We conclude that the absent recognition of the AC cannot generally be explained by insufficient processing and presentation at the cell surface of the AC.

AB - Allogeneic stem cell transplantation has emerged as immunotherapy in the treatment of a variety of hematological malignancies. Its efficacy depends on induction of graft versus leukemia by donor lymphocytes. Both graft versus leukemia and graft versus host disease are induced by T cells reactive against polymorphic peptides, called minor histocompatibility antigens (MiHA), which differ between patient and donor and are presented in the context of self-HLA (where HLA is human leukocyte antigen). The allelic counterpart (AC) of the MiHA is generally considered to be absent at the cell surface, based on the absence of immune responses directed against the AC. To study this in detail, we evaluate the recognition, HLA-binding affinity, and cell surface expression of three selected MiHA. By quantitative MS, we demonstrate the similarly abundant expression of both MiHA and AC at the cell surface. We conclude that the absent recognition of the AC cannot generally be explained by insufficient processing and presentation at the cell surface of the AC.

KW - Journal Article

U2 - 10.1002/pmic.201700250

DO - 10.1002/pmic.201700250

M3 - Article

VL - 18

JO - Proteomics

JF - Proteomics

SN - 1615-9853

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ER -