Abstract

Background: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). Objective: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. Methods: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL. The control group included 149 healthy living kidney donors. SV was determined on computed tomography. Results: The median SV in the uncomplicated CD group was significantly larger than in controls (202 cm3 (interquartile range (IQR): 154–275) versus 183 cm3 (IQR: 140–232), p = 0.02). After correction for body surface area, age and gender, the ratio of SV in uncomplicated CD versus controls was 1.28 (95% confidence interval: 1.20–1.36; p < 0.001). The median SV in RCD II patients (118 cm3 (IQR 83–181)) was smaller than the median SV in the control group (p < 0.001). Conclusion: This study demonstrates large inter-individual variation in SV. SV is enlarged in uncomplicated CD. The small SV in RCD II may be of clinical relevance considering the immune-compromised status of these patients.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalUnited European Gastroenterology Journal
Volume5
Issue number3
DOIs
Publication statusPublished - 1 Apr 2017

Cite this

@article{c086729be77b4ebe899c34384aefda03,
title = "Splenic volume differentiates complicated and non-complicated celiac disease",
abstract = "Background: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). Objective: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. Methods: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL. The control group included 149 healthy living kidney donors. SV was determined on computed tomography. Results: The median SV in the uncomplicated CD group was significantly larger than in controls (202 cm3 (interquartile range (IQR): 154–275) versus 183 cm3 (IQR: 140–232), p = 0.02). After correction for body surface area, age and gender, the ratio of SV in uncomplicated CD versus controls was 1.28 (95{\%} confidence interval: 1.20–1.36; p < 0.001). The median SV in RCD II patients (118 cm3 (IQR 83–181)) was smaller than the median SV in the control group (p < 0.001). Conclusion: This study demonstrates large inter-individual variation in SV. SV is enlarged in uncomplicated CD. The small SV in RCD II may be of clinical relevance considering the immune-compromised status of these patients.",
keywords = "Celiac disease, computed tomography, enteropathy-associated T-cell lymphoma, refractory celiac disease, spleen, splenic volume",
author = "{van Gils}, Tom and Petula Nijeboer and {van Waesberghe}, {Jan Hein TM} and Coup{\'e}, {Veerle M.H.} and Kiki Janssen and Zegers, {Jessy A.} and Nurmohamed, {Shaikh A.} and Georg Kraal and Jiskoot, {Sabine C.I.} and Gerd Bouma and Mulder, {Chris J.J.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1177/2050640616663571",
language = "English",
volume = "5",
pages = "374--379",
journal = "United European Gastroenterology Journal",
issn = "2050-6406",
publisher = "SAGE Publications Inc.",
number = "3",

}

Splenic volume differentiates complicated and non-complicated celiac disease. / van Gils, Tom; Nijeboer, Petula; van Waesberghe, Jan Hein TM; Coupé, Veerle M.H.; Janssen, Kiki; Zegers, Jessy A.; Nurmohamed, Shaikh A.; Kraal, Georg; Jiskoot, Sabine C.I.; Bouma, Gerd; Mulder, Chris J.J.

In: United European Gastroenterology Journal, Vol. 5, No. 3, 01.04.2017, p. 374-379.

Research output: Contribution to journalArticleProfessional

TY - JOUR

T1 - Splenic volume differentiates complicated and non-complicated celiac disease

AU - van Gils, Tom

AU - Nijeboer, Petula

AU - van Waesberghe, Jan Hein TM

AU - Coupé, Veerle M.H.

AU - Janssen, Kiki

AU - Zegers, Jessy A.

AU - Nurmohamed, Shaikh A.

AU - Kraal, Georg

AU - Jiskoot, Sabine C.I.

AU - Bouma, Gerd

AU - Mulder, Chris J.J.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). Objective: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. Methods: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL. The control group included 149 healthy living kidney donors. SV was determined on computed tomography. Results: The median SV in the uncomplicated CD group was significantly larger than in controls (202 cm3 (interquartile range (IQR): 154–275) versus 183 cm3 (IQR: 140–232), p = 0.02). After correction for body surface area, age and gender, the ratio of SV in uncomplicated CD versus controls was 1.28 (95% confidence interval: 1.20–1.36; p < 0.001). The median SV in RCD II patients (118 cm3 (IQR 83–181)) was smaller than the median SV in the control group (p < 0.001). Conclusion: This study demonstrates large inter-individual variation in SV. SV is enlarged in uncomplicated CD. The small SV in RCD II may be of clinical relevance considering the immune-compromised status of these patients.

AB - Background: Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). Objective: The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. Methods: The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL. The control group included 149 healthy living kidney donors. SV was determined on computed tomography. Results: The median SV in the uncomplicated CD group was significantly larger than in controls (202 cm3 (interquartile range (IQR): 154–275) versus 183 cm3 (IQR: 140–232), p = 0.02). After correction for body surface area, age and gender, the ratio of SV in uncomplicated CD versus controls was 1.28 (95% confidence interval: 1.20–1.36; p < 0.001). The median SV in RCD II patients (118 cm3 (IQR 83–181)) was smaller than the median SV in the control group (p < 0.001). Conclusion: This study demonstrates large inter-individual variation in SV. SV is enlarged in uncomplicated CD. The small SV in RCD II may be of clinical relevance considering the immune-compromised status of these patients.

KW - Celiac disease

KW - computed tomography

KW - enteropathy-associated T-cell lymphoma

KW - refractory celiac disease

KW - spleen

KW - splenic volume

UR - http://www.scopus.com/inward/record.url?scp=85019012166&partnerID=8YFLogxK

U2 - 10.1177/2050640616663571

DO - 10.1177/2050640616663571

M3 - Article

VL - 5

SP - 374

EP - 379

JO - United European Gastroenterology Journal

JF - United European Gastroenterology Journal

SN - 2050-6406

IS - 3

ER -