Stability of Cortisol and Cortisone in Human Breast Milk during Holder Pasteurization

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term. We found tight correlations between pre- and postpasteurization levels of cortisol (R2 = 0.99) and cortisone (R2 = 0.98), and good agreement in Passing and Bablok regression analysis. In conclusion, cortisol and cortisone in human term breast milk are not significantly affected by Holder pasteurization.

Original languageEnglish
Pages (from-to)658-660
Number of pages3
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume65
Issue number6
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

@article{a13078d96a394e098b9191f7cc22c520,
title = "Stability of Cortisol and Cortisone in Human Breast Milk during Holder Pasteurization",
abstract = "Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term. We found tight correlations between pre- and postpasteurization levels of cortisol (R2 = 0.99) and cortisone (R2 = 0.98), and good agreement in Passing and Bablok regression analysis. In conclusion, cortisol and cortisone in human term breast milk are not significantly affected by Holder pasteurization.",
keywords = "donor milk bank, mother's milk, premature infant, steroids",
author = "{Van Der Voorn}, Bibian and {De Waard}, Marita and Dijkstra, {Lisette R.} and Heijboer, {Annemieke C.} and Joost Rotteveel and {Van Goudoever}, {Johannes B.} and Finken, {Martijn J.J.}",
year = "2017",
month = "12",
day = "1",
doi = "10.1097/MPG.0000000000001678",
language = "English",
volume = "65",
pages = "658--660",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Stability of Cortisol and Cortisone in Human Breast Milk during Holder Pasteurization

AU - Van Der Voorn, Bibian

AU - De Waard, Marita

AU - Dijkstra, Lisette R.

AU - Heijboer, Annemieke C.

AU - Rotteveel, Joost

AU - Van Goudoever, Johannes B.

AU - Finken, Martijn J.J.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term. We found tight correlations between pre- and postpasteurization levels of cortisol (R2 = 0.99) and cortisone (R2 = 0.98), and good agreement in Passing and Bablok regression analysis. In conclusion, cortisol and cortisone in human term breast milk are not significantly affected by Holder pasteurization.

AB - Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term. We found tight correlations between pre- and postpasteurization levels of cortisol (R2 = 0.99) and cortisone (R2 = 0.98), and good agreement in Passing and Bablok regression analysis. In conclusion, cortisol and cortisone in human term breast milk are not significantly affected by Holder pasteurization.

KW - donor milk bank

KW - mother's milk

KW - premature infant

KW - steroids

UR - http://www.scopus.com/inward/record.url?scp=85021936838&partnerID=8YFLogxK

U2 - 10.1097/MPG.0000000000001678

DO - 10.1097/MPG.0000000000001678

M3 - Article

VL - 65

SP - 658

EP - 660

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 6

ER -