Statins are less effective in common daily practice among patients with hypercholesterolemia: the REALITY-PHARMO study

W. G. Goettsch; D. D. Yin; E. Alemao; O. H. Klungel; A. F. Stalenhoef; R. M. Herings

doi:10.1185/030079904125004114

Statins are less effective in common daily practice among patients with hypercholesterolemia: the REALITY-PHARMO study

W. G. Goettsch, D. D. Yin, E. Alemao, O. H. Klungel, A. F. Stalenhoef, R. M. Herings

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: To study the use and effectiveness of lipid-lowering drugs with respect to lowering of cholesterol levels in routine daily practice. METHODS: 20 392 patients for whom lipid levels records were available between January 1991 and December 2001 were included in this retrospective population based cohort study. From this group of patients 1899 patients started treatment during the study period and had at least one baseline cholesterol measurement during the six months prior to the initiation of lipid lowering drugs and at least one cholesterol measurement after initiation. A patient was defined to be 'at goal' if the patient had a total cholesterol less than 5.0 mmol/L. RESULTS: Our results indicate that only 30.2% of all treated patients achieved goal in the first year of treatment. After the introduction of new guidelines in 1998, recommending more aggressive treatment, the goal attainment percentage rose from 22.4% of those patients treated before 1998 to 42.3% for those in whom treatment was initiated after 1998. CONCLUSION: The percentage of patients achieving guideline recommended goal is low in real-life even in patients treated with high dose statins.

Original language	English
Pages (from-to)	1025-1033
Number of pages	9
Journal	Current Medical Research and Opinion
Volume	20
Issue number	7
DOIs	https://doi.org/10.1185/030079904125004114
Publication status	Published - 2004
Externally published	Yes

Access to Document

10.1185/030079904125004114

https://www.ncbi.nlm.nih.gov/pubmed/15265247

Cite this

@article{8b0ab2271b484e4799b7d2a02156610a,

title = "Statins are less effective in common daily practice among patients with hypercholesterolemia: the REALITY-PHARMO study",

abstract = "BACKGROUND: To study the use and effectiveness of lipid-lowering drugs with respect to lowering of cholesterol levels in routine daily practice. METHODS: 20 392 patients for whom lipid levels records were available between January 1991 and December 2001 were included in this retrospective population based cohort study. From this group of patients 1899 patients started treatment during the study period and had at least one baseline cholesterol measurement during the six months prior to the initiation of lipid lowering drugs and at least one cholesterol measurement after initiation. A patient was defined to be 'at goal' if the patient had a total cholesterol less than 5.0 mmol/L. RESULTS: Our results indicate that only 30.2% of all treated patients achieved goal in the first year of treatment. After the introduction of new guidelines in 1998, recommending more aggressive treatment, the goal attainment percentage rose from 22.4% of those patients treated before 1998 to 42.3% for those in whom treatment was initiated after 1998. CONCLUSION: The percentage of patients achieving guideline recommended goal is low in real-life even in patients treated with high dose statins.",

keywords = "Adult Aged Cholesterol/blood Cohort Studies Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/*therapeutic use Hypercholesterolemia/*drug therapy Male Middle Aged Netherlands Practice Guidelines as Topic Retrospective Studies Treatment Outcome",

author = "Goettsch, {W. G.} and Yin, {D. D.} and E. Alemao and Klungel, {O. H.} and Stalenhoef, {A. F.} and Herings, {R. M.}",

note = "Goettsch, Wim G Yin, Donald D Alemao, Evo Klungel, Olaf H Stalenhoef, Anton F Herings, Ron M C eng Research Support, Non-U.S. Gov't England Curr Med Res Opin. 2004 Jul;20(7):1025-33. doi: 10.1185/030079904125004114.",

year = "2004",

doi = "10.1185/030079904125004114",

language = "English",

volume = "20",

pages = "1025--1033",

journal = "Current Medical Research and Opinion",

issn = "0300-7995",

publisher = "Taylor and Francis Ltd.",

number = "7",

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TY - JOUR

T1 - Statins are less effective in common daily practice among patients with hypercholesterolemia: the REALITY-PHARMO study

AU - Goettsch, W. G.

AU - Yin, D. D.

AU - Alemao, E.

AU - Klungel, O. H.

AU - Stalenhoef, A. F.

AU - Herings, R. M.

N1 - Goettsch, Wim G Yin, Donald D Alemao, Evo Klungel, Olaf H Stalenhoef, Anton F Herings, Ron M C eng Research Support, Non-U.S. Gov't England Curr Med Res Opin. 2004 Jul;20(7):1025-33. doi: 10.1185/030079904125004114.

PY - 2004

Y1 - 2004

N2 - BACKGROUND: To study the use and effectiveness of lipid-lowering drugs with respect to lowering of cholesterol levels in routine daily practice. METHODS: 20 392 patients for whom lipid levels records were available between January 1991 and December 2001 were included in this retrospective population based cohort study. From this group of patients 1899 patients started treatment during the study period and had at least one baseline cholesterol measurement during the six months prior to the initiation of lipid lowering drugs and at least one cholesterol measurement after initiation. A patient was defined to be 'at goal' if the patient had a total cholesterol less than 5.0 mmol/L. RESULTS: Our results indicate that only 30.2% of all treated patients achieved goal in the first year of treatment. After the introduction of new guidelines in 1998, recommending more aggressive treatment, the goal attainment percentage rose from 22.4% of those patients treated before 1998 to 42.3% for those in whom treatment was initiated after 1998. CONCLUSION: The percentage of patients achieving guideline recommended goal is low in real-life even in patients treated with high dose statins.

AB - BACKGROUND: To study the use and effectiveness of lipid-lowering drugs with respect to lowering of cholesterol levels in routine daily practice. METHODS: 20 392 patients for whom lipid levels records were available between January 1991 and December 2001 were included in this retrospective population based cohort study. From this group of patients 1899 patients started treatment during the study period and had at least one baseline cholesterol measurement during the six months prior to the initiation of lipid lowering drugs and at least one cholesterol measurement after initiation. A patient was defined to be 'at goal' if the patient had a total cholesterol less than 5.0 mmol/L. RESULTS: Our results indicate that only 30.2% of all treated patients achieved goal in the first year of treatment. After the introduction of new guidelines in 1998, recommending more aggressive treatment, the goal attainment percentage rose from 22.4% of those patients treated before 1998 to 42.3% for those in whom treatment was initiated after 1998. CONCLUSION: The percentage of patients achieving guideline recommended goal is low in real-life even in patients treated with high dose statins.

KW - Adult Aged Cholesterol/blood Cohort Studies Female Follow-Up Studies Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/therapeutic use Hypercholesterolemia/drug therapy Male Middle Aged Netherlands Practice Guidelines as Topic Retrospecti

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DO - 10.1185/030079904125004114

M3 - Article

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VL - 20

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