Stereotactic radiosurgery with adjusted linear accelerator for cerebral arteriovenous malformations: preliminary results in the Netherlands

J G Wolbers, H C Mol, J H Kralendonk, O W Meijer, J C Baayen, B J Slotman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To assess the effects of stereotactic radiosurgery of a cerebral arteriovenous malformation (AVM).

DESIGN: Prospective.

METHOD: In November 1991-December 1995 linear acceleration radiosurgery was performed on 29 patients for their 30 cerebral AVMs in the University Hospital Vrije Universiteit, Amsterdam, the Netherlands. There were 15 females and 14 males with a mean age of 37.1 years (range: 13-58). Generally one isocentre was used and 15 Gy was given to the margins of the AVM at the 80% isodose. The mean target volume was 2.4 ml (range; 0.5-8.2). After 6 months, one year and thereafter every year, neurological and MRI-controls took place, in the outpatient ward. Angiography was performed after an average of 35 months (range: 24-70) to check if the AVM had obliterated.

RESULTS: Angiographic post-treatment results were available in 27 patients and MRI information in one. Angiographic obliteration occurred in 20 patients (71%). No permanent radiation-induced neurological deficit was seen, nor did any hemorrhage occur during the interval between irradiation and obliteration.

Translated title of the contributionStereotactic radiosurgery with adjusted linear accelerator for cerebral arteriovenous malformations: preliminary results in the Netherlands
Original languageDutch
Pages (from-to)1215-21
Number of pages7
JournalNederlands Tijdschrift voor Geneeskunde
Volume143
Issue number23
Publication statusPublished - 5 Jun 1999

Cite this

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title = "Stereotactische radiochirurgie met aangepaste lineaire versneller voor cerebrale arterioveneuze malformaties: eerste ervaringen in Nederland",
abstract = "OBJECTIVE: To assess the effects of stereotactic radiosurgery of a cerebral arteriovenous malformation (AVM).DESIGN: Prospective.METHOD: In November 1991-December 1995 linear acceleration radiosurgery was performed on 29 patients for their 30 cerebral AVMs in the University Hospital Vrije Universiteit, Amsterdam, the Netherlands. There were 15 females and 14 males with a mean age of 37.1 years (range: 13-58). Generally one isocentre was used and 15 Gy was given to the margins of the AVM at the 80{\%} isodose. The mean target volume was 2.4 ml (range; 0.5-8.2). After 6 months, one year and thereafter every year, neurological and MRI-controls took place, in the outpatient ward. Angiography was performed after an average of 35 months (range: 24-70) to check if the AVM had obliterated.RESULTS: Angiographic post-treatment results were available in 27 patients and MRI information in one. Angiographic obliteration occurred in 20 patients (71{\%}). No permanent radiation-induced neurological deficit was seen, nor did any hemorrhage occur during the interval between irradiation and obliteration.",
keywords = "Adolescent, Adult, Cerebral Angiography, Female, Follow-Up Studies, Humans, Intracranial Arteriovenous Malformations/diagnostic imaging, Male, Middle Aged, Prospective Studies, Radiation Dosage, Radiosurgery/methods, Stereotaxic Techniques, Treatment Outcome",
author = "Wolbers, {J G} and Mol, {H C} and Kralendonk, {J H} and Meijer, {O W} and Baayen, {J C} and Slotman, {B J}",
year = "1999",
month = "6",
day = "5",
language = "Dutch",
volume = "143",
pages = "1215--21",
journal = "Nederlands Tijdschrift voor Geneeskunde",
issn = "0028-2162",
publisher = "Bohn Stafleu van Loghum",
number = "23",

}

Stereotactische radiochirurgie met aangepaste lineaire versneller voor cerebrale arterioveneuze malformaties : eerste ervaringen in Nederland. / Wolbers, J G; Mol, H C; Kralendonk, J H; Meijer, O W; Baayen, J C; Slotman, B J.

In: Nederlands Tijdschrift voor Geneeskunde, Vol. 143, No. 23, 05.06.1999, p. 1215-21.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Stereotactische radiochirurgie met aangepaste lineaire versneller voor cerebrale arterioveneuze malformaties

T2 - eerste ervaringen in Nederland

AU - Wolbers, J G

AU - Mol, H C

AU - Kralendonk, J H

AU - Meijer, O W

AU - Baayen, J C

AU - Slotman, B J

PY - 1999/6/5

Y1 - 1999/6/5

N2 - OBJECTIVE: To assess the effects of stereotactic radiosurgery of a cerebral arteriovenous malformation (AVM).DESIGN: Prospective.METHOD: In November 1991-December 1995 linear acceleration radiosurgery was performed on 29 patients for their 30 cerebral AVMs in the University Hospital Vrije Universiteit, Amsterdam, the Netherlands. There were 15 females and 14 males with a mean age of 37.1 years (range: 13-58). Generally one isocentre was used and 15 Gy was given to the margins of the AVM at the 80% isodose. The mean target volume was 2.4 ml (range; 0.5-8.2). After 6 months, one year and thereafter every year, neurological and MRI-controls took place, in the outpatient ward. Angiography was performed after an average of 35 months (range: 24-70) to check if the AVM had obliterated.RESULTS: Angiographic post-treatment results were available in 27 patients and MRI information in one. Angiographic obliteration occurred in 20 patients (71%). No permanent radiation-induced neurological deficit was seen, nor did any hemorrhage occur during the interval between irradiation and obliteration.

AB - OBJECTIVE: To assess the effects of stereotactic radiosurgery of a cerebral arteriovenous malformation (AVM).DESIGN: Prospective.METHOD: In November 1991-December 1995 linear acceleration radiosurgery was performed on 29 patients for their 30 cerebral AVMs in the University Hospital Vrije Universiteit, Amsterdam, the Netherlands. There were 15 females and 14 males with a mean age of 37.1 years (range: 13-58). Generally one isocentre was used and 15 Gy was given to the margins of the AVM at the 80% isodose. The mean target volume was 2.4 ml (range; 0.5-8.2). After 6 months, one year and thereafter every year, neurological and MRI-controls took place, in the outpatient ward. Angiography was performed after an average of 35 months (range: 24-70) to check if the AVM had obliterated.RESULTS: Angiographic post-treatment results were available in 27 patients and MRI information in one. Angiographic obliteration occurred in 20 patients (71%). No permanent radiation-induced neurological deficit was seen, nor did any hemorrhage occur during the interval between irradiation and obliteration.

KW - Adolescent

KW - Adult

KW - Cerebral Angiography

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Intracranial Arteriovenous Malformations/diagnostic imaging

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Radiation Dosage

KW - Radiosurgery/methods

KW - Stereotaxic Techniques

KW - Treatment Outcome

M3 - Article

VL - 143

SP - 1215

EP - 1221

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

SN - 0028-2162

IS - 23

ER -