Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images

Alwin Zweerink, Cornelis P. Allaart, Joost P.A. Kuijer, Li Na Wu, Aernout M. Beek, Peter M. van de Ven, Mathias Meine, Pierre Croisille, Patrick Clarysse, Albert C. van Rossum, Robin Nijveldt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives: Although myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates. Methods: Twenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG). SLICE was performed by measuring segment length between anatomical landmarks throughout all phases on short-axis cines. This measure of frame-to-frame segment length change was compared to CMR-TAG circumferential strain measurements. Subsequently, conventional markers of CRT response were calculated. Results: Segmental strains showed good to excellent agreement between SLICE and CMR-TAG (septum strain, intraclass correlation coefficient (ICC) 0.76; lateral wall strain, ICC 0.66). Conventional markers of CRT response also showed close agreement between both methods (ICC 0.61–0.78). Reproducibility of SLICE was excellent for intra-observer testing (all ICC ≥0.76) and good for interobserver testing (all ICC ≥0.61). Conclusions: The novel SLICE post-processing technique on standard CMR cine images offers both accurate and robust segmental strain measures compared to the ‘gold standard’ CMR-TAG technique, and has the advantage of being widely available. Key Points: • Myocardial strain analysis could potentially improve patient selection for CRT. • Currently a well validated clinical approach to derive segmental strains is lacking. • The novel SLICE technique derives segmental strains from standard CMR cine images. • SLICE-derived strain markers of CRT response showed close agreement with CMR-TAG. • Future studies will focus on the prognostic value of SLICE in CRT candidates.

LanguageEnglish
Pages5158-5168
Number of pages11
JournalEuropean Radiology
Volume27
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

@article{dec6e73f44364a22b888f7dd5ad7287d,
title = "Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images",
abstract = "Objectives: Although myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates. Methods: Twenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG). SLICE was performed by measuring segment length between anatomical landmarks throughout all phases on short-axis cines. This measure of frame-to-frame segment length change was compared to CMR-TAG circumferential strain measurements. Subsequently, conventional markers of CRT response were calculated. Results: Segmental strains showed good to excellent agreement between SLICE and CMR-TAG (septum strain, intraclass correlation coefficient (ICC) 0.76; lateral wall strain, ICC 0.66). Conventional markers of CRT response also showed close agreement between both methods (ICC 0.61–0.78). Reproducibility of SLICE was excellent for intra-observer testing (all ICC ≥0.76) and good for interobserver testing (all ICC ≥0.61). Conclusions: The novel SLICE post-processing technique on standard CMR cine images offers both accurate and robust segmental strain measures compared to the ‘gold standard’ CMR-TAG technique, and has the advantage of being widely available. Key Points: • Myocardial strain analysis could potentially improve patient selection for CRT. • Currently a well validated clinical approach to derive segmental strains is lacking. • The novel SLICE technique derives segmental strains from standard CMR cine images. • SLICE-derived strain markers of CRT response showed close agreement with CMR-TAG. • Future studies will focus on the prognostic value of SLICE in CRT candidates.",
keywords = "Cardiac Resynchronization Therapy (CRT), Cardiovascular magnetic resonance (CMR), Myocardial strain analysis, Myocardial tagging (CMR-TAG), Segment length in cine (SLICE) technique",
author = "Alwin Zweerink and Allaart, {Cornelis P.} and Kuijer, {Joost P.A.} and Wu, {Li Na} and Beek, {Aernout M.} and {van de Ven}, {Peter M.} and Mathias Meine and Pierre Croisille and Patrick Clarysse and {van Rossum}, {Albert C.} and Robin Nijveldt",
year = "2017",
month = "12",
day = "1",
doi = "10.1007/s00330-017-4890-0",
language = "English",
volume = "27",
pages = "5158--5168",
journal = "European Radiology",
issn = "0938-7994",
publisher = "Springer Verlag",
number = "12",

}

Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images. / Zweerink, Alwin; Allaart, Cornelis P.; Kuijer, Joost P.A.; Wu, Li Na; Beek, Aernout M.; van de Ven, Peter M.; Meine, Mathias; Croisille, Pierre; Clarysse, Patrick; van Rossum, Albert C.; Nijveldt, Robin.

In: European Radiology, Vol. 27, No. 12, 01.12.2017, p. 5158-5168.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images

AU - Zweerink, Alwin

AU - Allaart, Cornelis P.

AU - Kuijer, Joost P.A.

AU - Wu, Li Na

AU - Beek, Aernout M.

AU - van de Ven, Peter M.

AU - Meine, Mathias

AU - Croisille, Pierre

AU - Clarysse, Patrick

AU - van Rossum, Albert C.

AU - Nijveldt, Robin

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objectives: Although myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates. Methods: Twenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG). SLICE was performed by measuring segment length between anatomical landmarks throughout all phases on short-axis cines. This measure of frame-to-frame segment length change was compared to CMR-TAG circumferential strain measurements. Subsequently, conventional markers of CRT response were calculated. Results: Segmental strains showed good to excellent agreement between SLICE and CMR-TAG (septum strain, intraclass correlation coefficient (ICC) 0.76; lateral wall strain, ICC 0.66). Conventional markers of CRT response also showed close agreement between both methods (ICC 0.61–0.78). Reproducibility of SLICE was excellent for intra-observer testing (all ICC ≥0.76) and good for interobserver testing (all ICC ≥0.61). Conclusions: The novel SLICE post-processing technique on standard CMR cine images offers both accurate and robust segmental strain measures compared to the ‘gold standard’ CMR-TAG technique, and has the advantage of being widely available. Key Points: • Myocardial strain analysis could potentially improve patient selection for CRT. • Currently a well validated clinical approach to derive segmental strains is lacking. • The novel SLICE technique derives segmental strains from standard CMR cine images. • SLICE-derived strain markers of CRT response showed close agreement with CMR-TAG. • Future studies will focus on the prognostic value of SLICE in CRT candidates.

AB - Objectives: Although myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates. Methods: Twenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG). SLICE was performed by measuring segment length between anatomical landmarks throughout all phases on short-axis cines. This measure of frame-to-frame segment length change was compared to CMR-TAG circumferential strain measurements. Subsequently, conventional markers of CRT response were calculated. Results: Segmental strains showed good to excellent agreement between SLICE and CMR-TAG (septum strain, intraclass correlation coefficient (ICC) 0.76; lateral wall strain, ICC 0.66). Conventional markers of CRT response also showed close agreement between both methods (ICC 0.61–0.78). Reproducibility of SLICE was excellent for intra-observer testing (all ICC ≥0.76) and good for interobserver testing (all ICC ≥0.61). Conclusions: The novel SLICE post-processing technique on standard CMR cine images offers both accurate and robust segmental strain measures compared to the ‘gold standard’ CMR-TAG technique, and has the advantage of being widely available. Key Points: • Myocardial strain analysis could potentially improve patient selection for CRT. • Currently a well validated clinical approach to derive segmental strains is lacking. • The novel SLICE technique derives segmental strains from standard CMR cine images. • SLICE-derived strain markers of CRT response showed close agreement with CMR-TAG. • Future studies will focus on the prognostic value of SLICE in CRT candidates.

KW - Cardiac Resynchronization Therapy (CRT)

KW - Cardiovascular magnetic resonance (CMR)

KW - Myocardial strain analysis

KW - Myocardial tagging (CMR-TAG)

KW - Segment length in cine (SLICE) technique

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U2 - 10.1007/s00330-017-4890-0

DO - 10.1007/s00330-017-4890-0

M3 - Article

VL - 27

SP - 5158

EP - 5168

JO - European Radiology

T2 - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 12

ER -