Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques

Alwin Zweerink, Wouter M. van Everdingen, Robin Nijveldt, Odette A. E. Salden, Mathias Meine, Alexander H. Maass, Kevin Vernooy, Frederik J. de Lange, Marc A. Vos, Pierre Croisille, Patrick Clarysse, Bastiaan Geelhoed, Michiel Rienstra, Isabelle C. van Gelder, Albert C. van Rossum, Maarten J. Cramer, Cornelis P. Allaart

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aims: Various strain parameters and multiple imaging techniques are presently available including cardiovascular magnetic resonance (CMR) tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE). This study aims to compare predictive performance of different strain parameters and evaluate results per imaging technique to predict cardiac resynchronization therapy (CRT) response. Methods and results: Twenty-seven patients were prospectively enrolled and underwent CMR and echocardiographic examination before CRT implantation. Strain analysis was performed in circumferential (CMR-TAG, CMR-FT, and STE-circ) and longitudinal (STE-long) orientations. Regional strain values, parameters of dyssynchrony, and discoordination were calculated. After 12 months, CRT response was measured by the echocardiographic change in left ventricular (LV) end-systolic volume (LVESV). Twenty-six patients completed follow-up; mean LVESV change was −29 ± 27% with 17 (65%) patients showing ≥15% LVESV reduction. Measures of dyssynchrony (SD-TTPLV) and discoordination (ISFLV) were strongly related to CRT response when using CMR-TAG (R2 0.61 and R2 0.57, respectively), but showed poor correlations for CMR-FT and STE (all R2 ≤ 0.32). In contrast, the end-systolic septal strain (ESSsep) parameter showed a consistent high correlation with LVESV change for all techniques (CMR-TAG R2 0.60; CMR-FT R2 0.50; STE-circ R2 0.43; and STE-long R2 0.43). After adjustment for QRS duration and QRS morphology, ESSsep remained an independent predictor of response per technique. Conclusions: End-systolic septal strain was the only parameter with a consistent good relation to reverse remodelling after CRT, irrespective of assessment technique. In clinical practice, this measure can be obtained by any available strain imaging technique and provides predictive value on top of current guideline criteria.
LanguageEnglish
Pages1130-1140
JournalESC Heart Failure
Volume5
Issue number6
DOIs
Publication statusPublished - 2018

Cite this

Zweerink, Alwin ; van Everdingen, Wouter M. ; Nijveldt, Robin ; Salden, Odette A. E. ; Meine, Mathias ; Maass, Alexander H. ; Vernooy, Kevin ; de Lange, Frederik J. ; Vos, Marc A. ; Croisille, Pierre ; Clarysse, Patrick ; Geelhoed, Bastiaan ; Rienstra, Michiel ; van Gelder, Isabelle C. ; van Rossum, Albert C. ; Cramer, Maarten J. ; Allaart, Cornelis P. / Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques. In: ESC Heart Failure. 2018 ; Vol. 5, No. 6. pp. 1130-1140.
@article{82967b54133949ad9bff403f482278f3,
title = "Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques",
abstract = "Aims: Various strain parameters and multiple imaging techniques are presently available including cardiovascular magnetic resonance (CMR) tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE). This study aims to compare predictive performance of different strain parameters and evaluate results per imaging technique to predict cardiac resynchronization therapy (CRT) response. Methods and results: Twenty-seven patients were prospectively enrolled and underwent CMR and echocardiographic examination before CRT implantation. Strain analysis was performed in circumferential (CMR-TAG, CMR-FT, and STE-circ) and longitudinal (STE-long) orientations. Regional strain values, parameters of dyssynchrony, and discoordination were calculated. After 12 months, CRT response was measured by the echocardiographic change in left ventricular (LV) end-systolic volume (LVESV). Twenty-six patients completed follow-up; mean LVESV change was −29 ± 27{\%} with 17 (65{\%}) patients showing ≥15{\%} LVESV reduction. Measures of dyssynchrony (SD-TTPLV) and discoordination (ISFLV) were strongly related to CRT response when using CMR-TAG (R2 0.61 and R2 0.57, respectively), but showed poor correlations for CMR-FT and STE (all R2 ≤ 0.32). In contrast, the end-systolic septal strain (ESSsep) parameter showed a consistent high correlation with LVESV change for all techniques (CMR-TAG R2 0.60; CMR-FT R2 0.50; STE-circ R2 0.43; and STE-long R2 0.43). After adjustment for QRS duration and QRS morphology, ESSsep remained an independent predictor of response per technique. Conclusions: End-systolic septal strain was the only parameter with a consistent good relation to reverse remodelling after CRT, irrespective of assessment technique. In clinical practice, this measure can be obtained by any available strain imaging technique and provides predictive value on top of current guideline criteria.",
author = "Alwin Zweerink and {van Everdingen}, {Wouter M.} and Robin Nijveldt and Salden, {Odette A. E.} and Mathias Meine and Maass, {Alexander H.} and Kevin Vernooy and {de Lange}, {Frederik J.} and Vos, {Marc A.} and Pierre Croisille and Patrick Clarysse and Bastiaan Geelhoed and Michiel Rienstra and {van Gelder}, {Isabelle C.} and {van Rossum}, {Albert C.} and Cramer, {Maarten J.} and Allaart, {Cornelis P.}",
year = "2018",
doi = "10.1002/ehf2.12335",
language = "English",
volume = "5",
pages = "1130--1140",
journal = "ESC Heart Failure",
issn = "2055-5822",
publisher = "The Heart Failure Association of the European Society of Cardiology",
number = "6",

}

Zweerink, A, van Everdingen, WM, Nijveldt, R, Salden, OAE, Meine, M, Maass, AH, Vernooy, K, de Lange, FJ, Vos, MA, Croisille, P, Clarysse, P, Geelhoed, B, Rienstra, M, van Gelder, IC, van Rossum, AC, Cramer, MJ & Allaart, CP 2018, 'Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques', ESC Heart Failure, vol. 5, no. 6, pp. 1130-1140. https://doi.org/10.1002/ehf2.12335

Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques. / Zweerink, Alwin; van Everdingen, Wouter M.; Nijveldt, Robin; Salden, Odette A. E.; Meine, Mathias; Maass, Alexander H.; Vernooy, Kevin; de Lange, Frederik J.; Vos, Marc A.; Croisille, Pierre; Clarysse, Patrick; Geelhoed, Bastiaan; Rienstra, Michiel; van Gelder, Isabelle C.; van Rossum, Albert C.; Cramer, Maarten J.; Allaart, Cornelis P.

In: ESC Heart Failure, Vol. 5, No. 6, 2018, p. 1130-1140.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Strain imaging to predict response to cardiac resynchronization therapy: a systematic comparison of strain parameters using multiple imaging techniques

AU - Zweerink, Alwin

AU - van Everdingen, Wouter M.

AU - Nijveldt, Robin

AU - Salden, Odette A. E.

AU - Meine, Mathias

AU - Maass, Alexander H.

AU - Vernooy, Kevin

AU - de Lange, Frederik J.

AU - Vos, Marc A.

AU - Croisille, Pierre

AU - Clarysse, Patrick

AU - Geelhoed, Bastiaan

AU - Rienstra, Michiel

AU - van Gelder, Isabelle C.

AU - van Rossum, Albert C.

AU - Cramer, Maarten J.

AU - Allaart, Cornelis P.

PY - 2018

Y1 - 2018

N2 - Aims: Various strain parameters and multiple imaging techniques are presently available including cardiovascular magnetic resonance (CMR) tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE). This study aims to compare predictive performance of different strain parameters and evaluate results per imaging technique to predict cardiac resynchronization therapy (CRT) response. Methods and results: Twenty-seven patients were prospectively enrolled and underwent CMR and echocardiographic examination before CRT implantation. Strain analysis was performed in circumferential (CMR-TAG, CMR-FT, and STE-circ) and longitudinal (STE-long) orientations. Regional strain values, parameters of dyssynchrony, and discoordination were calculated. After 12 months, CRT response was measured by the echocardiographic change in left ventricular (LV) end-systolic volume (LVESV). Twenty-six patients completed follow-up; mean LVESV change was −29 ± 27% with 17 (65%) patients showing ≥15% LVESV reduction. Measures of dyssynchrony (SD-TTPLV) and discoordination (ISFLV) were strongly related to CRT response when using CMR-TAG (R2 0.61 and R2 0.57, respectively), but showed poor correlations for CMR-FT and STE (all R2 ≤ 0.32). In contrast, the end-systolic septal strain (ESSsep) parameter showed a consistent high correlation with LVESV change for all techniques (CMR-TAG R2 0.60; CMR-FT R2 0.50; STE-circ R2 0.43; and STE-long R2 0.43). After adjustment for QRS duration and QRS morphology, ESSsep remained an independent predictor of response per technique. Conclusions: End-systolic septal strain was the only parameter with a consistent good relation to reverse remodelling after CRT, irrespective of assessment technique. In clinical practice, this measure can be obtained by any available strain imaging technique and provides predictive value on top of current guideline criteria.

AB - Aims: Various strain parameters and multiple imaging techniques are presently available including cardiovascular magnetic resonance (CMR) tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE). This study aims to compare predictive performance of different strain parameters and evaluate results per imaging technique to predict cardiac resynchronization therapy (CRT) response. Methods and results: Twenty-seven patients were prospectively enrolled and underwent CMR and echocardiographic examination before CRT implantation. Strain analysis was performed in circumferential (CMR-TAG, CMR-FT, and STE-circ) and longitudinal (STE-long) orientations. Regional strain values, parameters of dyssynchrony, and discoordination were calculated. After 12 months, CRT response was measured by the echocardiographic change in left ventricular (LV) end-systolic volume (LVESV). Twenty-six patients completed follow-up; mean LVESV change was −29 ± 27% with 17 (65%) patients showing ≥15% LVESV reduction. Measures of dyssynchrony (SD-TTPLV) and discoordination (ISFLV) were strongly related to CRT response when using CMR-TAG (R2 0.61 and R2 0.57, respectively), but showed poor correlations for CMR-FT and STE (all R2 ≤ 0.32). In contrast, the end-systolic septal strain (ESSsep) parameter showed a consistent high correlation with LVESV change for all techniques (CMR-TAG R2 0.60; CMR-FT R2 0.50; STE-circ R2 0.43; and STE-long R2 0.43). After adjustment for QRS duration and QRS morphology, ESSsep remained an independent predictor of response per technique. Conclusions: End-systolic septal strain was the only parameter with a consistent good relation to reverse remodelling after CRT, irrespective of assessment technique. In clinical practice, this measure can be obtained by any available strain imaging technique and provides predictive value on top of current guideline criteria.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058877506&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30051598

U2 - 10.1002/ehf2.12335

DO - 10.1002/ehf2.12335

M3 - Article

VL - 5

SP - 1130

EP - 1140

JO - ESC Heart Failure

T2 - ESC Heart Failure

JF - ESC Heart Failure

SN - 2055-5822

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ER -