TY - JOUR
T1 - Strategic white matter hyperintensity locations for cognitive impairment
T2 - A multicenter lesion-symptom mapping study in 3525 memory clinic patients
AU - Coenen, Mirthe
AU - Kuijf, Hugo J.
AU - Huenges Wajer, Irene M. C.
AU - Duering, Marco
AU - Wolters, Frank J.
AU - Fletcher, Evan F.
AU - Maillard, Pauline M.
AU - Barkhof, Frederik
AU - Barnes, Josephine
AU - Benke, Thomas
AU - Boomsma, Jooske M. F.
AU - Chen, Christopher P. L. H.
AU - Dal-Bianco, Peter
AU - Dewenter, Anna
AU - Enzinger, Christian
AU - Ewers, Michael
AU - Exalto, Lieza G.
AU - Franzmeier, Nicolai
AU - Groeneveld, Onno
AU - Hilal, Saima
AU - Hofer, Edith
AU - Koek, Dineke L.
AU - Maier, Andrea B.
AU - McCreary, Cheryl R.
AU - Padilla, Catarina S.
AU - Papma, Janne M.
AU - Paterson, Ross W.
AU - Pijnenburg, Yolande A. L.
AU - Rubinski, Anna
AU - Schmidt, Reinhold
AU - Schott, Jonathan M.
AU - Slattery, Catherine F.
AU - Smith, Eric E.
AU - Steketee, Rebecca M. E.
AU - Sudre, Carole H.
AU - van den Berg, Esther
AU - van der Flier, Wiesje M.
AU - Venketasubramanian, Narayanaswamy
AU - Vernooij, Meike W.
AU - Xin, Xu
AU - DeCarli, Charles
AU - Biessels, Geert Jan
AU - Biesbroek, J. Matthijs
AU - Alzheimer's Disease Neuroimaging Initiative
PY - 2022
Y1 - 2022
N2 - Introduction: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. Methods: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses. Results: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains. Discussion: The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. Highlights: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
AB - Introduction: Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is lacking. We aimed to identify these locations in a large multicenter study. Methods: Individual patient data (n = 3525) from 11 memory clinic cohorts were harmonized. We determined the association of WMH location with attention and executive functioning, information processing speed, language, and verbal memory performance using voxel-based and region of interest tract-based analyses. Results: WMH in the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus were significantly related to domain-specific impairment, independent of total WMH volume and atrophy. A strategic WMH score based on these tracts inversely correlated with performance in all domains. Discussion: The data show that the impact of WMH on cognition is location-dependent, primarily involving four strategic white matter tracts. Evaluation of WMH location may support diagnosing vascular cognitive impairment. Highlights: We analyzed white matter hyperintensities (WMH) in 3525 memory clinic patients from 11 cohorts The impact of WMH on cognition depends on location We identified four strategic white matter tracts A single strategic WMH score was derived from these four strategic tracts The strategic WMH score was an independent determinant of four cognitive domains.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149705877&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36504357
U2 - 10.1002/alz.12827
DO - 10.1002/alz.12827
M3 - Article
C2 - 36504357
SN - 1552-5260
JO - Alzheimers & Dementia
JF - Alzheimers & Dementia
ER -