Structural changes of atrial myocardium during chronic atrial fibrillation

V L Thijssen, J Ausma, G S Liu, M A Allessie, G J van Eys, M Borgers

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Of all known arrhythmia's, atrial fibrillation (AF) is the most often met in the clinical setting and it is associated with an increase in mortality risk. Several risk factors for AF have been described and several mechanisms of induction and maintenance have been proposed. Studies in patients with AF have shown that structural changes occur in the atria, but the relationship between the structural remodelling and the chronicity of the arrhythmia are not well understood. The changes mainly concern adaptive (dedifferentiation of cardiomyocytes) and maladaptive (degeneration of cells with replacement fibrosis) features. In order to characterise the time course of the structural remodelling the need for animal models which adequately mimic chronic atrial fibrillation in humans is felt essential. In this review, the structural changes that are observed during prolonged sustained AF in patients and animal models, are described. Furthermore, the time course and potential mechanisms of structural remodelling are discussed and methods for elucidation of the underlying molecular mechanisms are presented.

Original languageEnglish
Pages (from-to)17-28
Number of pages12
JournalCardiovascular Pathology
Volume9
Issue number1
Publication statusPublished - 31 Mar 2000
Externally publishedYes

Cite this

Thijssen, V. L., Ausma, J., Liu, G. S., Allessie, M. A., van Eys, G. J., & Borgers, M. (2000). Structural changes of atrial myocardium during chronic atrial fibrillation. Cardiovascular Pathology, 9(1), 17-28.
Thijssen, V L ; Ausma, J ; Liu, G S ; Allessie, M A ; van Eys, G J ; Borgers, M. / Structural changes of atrial myocardium during chronic atrial fibrillation. In: Cardiovascular Pathology. 2000 ; Vol. 9, No. 1. pp. 17-28.
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Thijssen, VL, Ausma, J, Liu, GS, Allessie, MA, van Eys, GJ & Borgers, M 2000, 'Structural changes of atrial myocardium during chronic atrial fibrillation' Cardiovascular Pathology, vol. 9, no. 1, pp. 17-28.

Structural changes of atrial myocardium during chronic atrial fibrillation. / Thijssen, V L; Ausma, J; Liu, G S; Allessie, M A; van Eys, G J; Borgers, M.

In: Cardiovascular Pathology, Vol. 9, No. 1, 31.03.2000, p. 17-28.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Structural changes of atrial myocardium during chronic atrial fibrillation

AU - Thijssen, V L

AU - Ausma, J

AU - Liu, G S

AU - Allessie, M A

AU - van Eys, G J

AU - Borgers, M

PY - 2000/3/31

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N2 - Of all known arrhythmia's, atrial fibrillation (AF) is the most often met in the clinical setting and it is associated with an increase in mortality risk. Several risk factors for AF have been described and several mechanisms of induction and maintenance have been proposed. Studies in patients with AF have shown that structural changes occur in the atria, but the relationship between the structural remodelling and the chronicity of the arrhythmia are not well understood. The changes mainly concern adaptive (dedifferentiation of cardiomyocytes) and maladaptive (degeneration of cells with replacement fibrosis) features. In order to characterise the time course of the structural remodelling the need for animal models which adequately mimic chronic atrial fibrillation in humans is felt essential. In this review, the structural changes that are observed during prolonged sustained AF in patients and animal models, are described. Furthermore, the time course and potential mechanisms of structural remodelling are discussed and methods for elucidation of the underlying molecular mechanisms are presented.

AB - Of all known arrhythmia's, atrial fibrillation (AF) is the most often met in the clinical setting and it is associated with an increase in mortality risk. Several risk factors for AF have been described and several mechanisms of induction and maintenance have been proposed. Studies in patients with AF have shown that structural changes occur in the atria, but the relationship between the structural remodelling and the chronicity of the arrhythmia are not well understood. The changes mainly concern adaptive (dedifferentiation of cardiomyocytes) and maladaptive (degeneration of cells with replacement fibrosis) features. In order to characterise the time course of the structural remodelling the need for animal models which adequately mimic chronic atrial fibrillation in humans is felt essential. In this review, the structural changes that are observed during prolonged sustained AF in patients and animal models, are described. Furthermore, the time course and potential mechanisms of structural remodelling are discussed and methods for elucidation of the underlying molecular mechanisms are presented.

KW - Actins/metabolism

KW - Animals

KW - Atrial Fibrillation/pathology

KW - Chronic Disease

KW - Disease Models, Animal

KW - Dogs

KW - Goats

KW - Heart Atria/metabolism

KW - Humans

KW - Myocardium/metabolism

KW - Ventricular Remodeling/physiology

M3 - Review article

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Thijssen VL, Ausma J, Liu GS, Allessie MA, van Eys GJ, Borgers M. Structural changes of atrial myocardium during chronic atrial fibrillation. Cardiovascular Pathology. 2000 Mar 31;9(1):17-28.