Subclinical cardiac dysfunction and brain health in midlife: CARDIA (Coronary Artery Risk Development in Young Adults) brain magnetic resonance imaging substudy

Pavla Cermakova, Majon Muller, Anderson C. Armstrong, Dorota Religa, R. Nick Bryan, João A.C. Lima, Lenore J. Launer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background--We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. Methods and Results--This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=-0.002; P < 0.02). The association was strongest in black participants and in men. Conclusions--Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.

Original languageEnglish
Article numbere006750
JournalJournal of the American Heart Association
Volume6
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

Cermakova, Pavla ; Muller, Majon ; Armstrong, Anderson C. ; Religa, Dorota ; Nick Bryan, R. ; Lima, João A.C. ; Launer, Lenore J. / Subclinical cardiac dysfunction and brain health in midlife : CARDIA (Coronary Artery Risk Development in Young Adults) brain magnetic resonance imaging substudy. In: Journal of the American Heart Association. 2017 ; Vol. 6, No. 12.
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Subclinical cardiac dysfunction and brain health in midlife : CARDIA (Coronary Artery Risk Development in Young Adults) brain magnetic resonance imaging substudy. / Cermakova, Pavla; Muller, Majon; Armstrong, Anderson C.; Religa, Dorota; Nick Bryan, R.; Lima, João A.C.; Launer, Lenore J.

In: Journal of the American Heart Association, Vol. 6, No. 12, e006750, 01.12.2017.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Subclinical cardiac dysfunction and brain health in midlife

T2 - CARDIA (Coronary Artery Risk Development in Young Adults) brain magnetic resonance imaging substudy

AU - Cermakova, Pavla

AU - Muller, Majon

AU - Armstrong, Anderson C.

AU - Religa, Dorota

AU - Nick Bryan, R.

AU - Lima, João A.C.

AU - Launer, Lenore J.

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AB - Background--We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. Methods and Results--This study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=-0.002; P < 0.02). The association was strongest in black participants and in men. Conclusions--Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.

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